ARTHROTEC 50
Generic Name for ARTHROTEC 50
Diclofenac sodium 50mg (e-c), misoprostol 200micrograms; tabs.
Legal Classification:
Rx
Pharmacological Class for ARTHROTEC 50
NSAID + prostaglandin E1 analogue.
Manufacturer of ARTHROTEC 50
Pfizer Labs
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Indications for ARTHROTEC 50
Osteoarthritis (OA) or rheumatoid arthritis (RA) in patients at high risk for developing NSAID-induced gastric or duodenal ulcers.
Adult dose for ARTHROTEC 50
Swallow whole; food may reduce diarrhea. ≥18yrs: OA: one Arthrotec 50 tab 3 times daily. RA: one Arthrotec 50 tab 3–4 times daily. Both: if not tolerated, may reduce to one Arthrotec 50 or one Arthrotec 75 tablet twice daily (this may be less effective in preventing ulcers). See literature.
Children's dosing for ARTHROTEC 50
<18yrs: not recommended.
Also:
Contraindications for ARTHROTEC 50
Pregnancy (Cat.X). Aspirin allergy. Coronary artery bypass graft surgery.
Warnings/Precautions for ARTHROTEC 50
For women of childbearing potential: obtain negative serum pregnancy test within 2 weeks before start of therapy; begin Arthrotec therapy on 2nd or 3rd day of menstrual period; maintain contraception during therapy; give oral and written warnings on risks in pregnancy. History of ulcer disease or GI bleeding. Inflammatory bowel disease. Cardiovascular disease. Edema. Heart failure. Hypertension. Asthma. Hepatic or renal dysfunction. Monitor CBCs, blood chemistry, hepatic and renal function. Check ALT (SGPT) within 4–8 wks then periodically. Discontinue if signs/symptoms of liver or renal disease develop, or if abnormal liver function tests persist or worsen. Hepatic porphyria. Dehydration. SLE. Elderly. Debilitated. Labor & delivery. Nursing mothers: not recommended.
Interactions for ARTHROTEC 50
Avoid magnesium-containing antacids, salicylates, aspirin, other NSAIDs. May antagonize ACE-inhibitors, diuretics. Digoxin, methotrexate, cyclosporine, lithium, warfarin toxicity. Hyper- or hypoglycemia possible with insulin, oral hypoglycemic agents. Increased risk of GI bleed with oral corticosteroids, anticoagulants (monitor), alcohol, smoking, prolonged NSAID therapy. Increased serum potassium with K+-sparing diuretics.
Adverse Reactions for ARTHROTEC 50
Abdominal pain, diarrhea, dyspepsia, nausea, flatulence, GI bleed/ulcer, other GI disturbances, rash (may be serious, eg, Stevens Johnson Syndrome; discontinue if occurs), elevated transaminase levels, anemia; anaphylactic reactions, aseptic meningitis (rare). See literature re: risk of cardiovascular events.
How is ARTHROTEC 50 supplied?
Arthrotec 50—60, 90
Arthrotec 75—60
Related Disease:
Arthritis~NSAIDs
Rheumatoid arthritis