Arthritis/rheumatic Disorders

Oral Contraceptives May Reduce Rheumatoid Arthritis Risk

August 21, 2017

The researchers found that ever and past OC users had a reduced risk of anticitrullinated protein antibodies (ACPA)-positive RA compared with never users.

Are OTC Lidocaine Patches as Effective as Rx for Localized Pain?

By August 15, 2017

Study authors sought to compare OTC lidocaine 3.6% with menthol 1.25% patches vs. Rx lidocaine 5% as well as to placebo.

Certain Occupations May Increase the Risk for Rheumatoid Arthritis

August 11, 2017

Assistant nurses and attendants had a moderately increased risk of ACPA+ RA among women (odds ratio, 1.3; 95% CI, 1.1 to 1.6), while no occupations correlated significantly with ACPA− RA.

FDA Panel Recommends Approval of Tofacitinib for Psoriatic Arthritis

By August 04, 2017

The supplemental New Drug Applications (sNDAs) contained data from Phase 3 trials involving patients with psoriatic arthritis, including safety analyses from the larger tofacitinib clinical development program.

FDA Committee Votes Against RA Drug Candidate Approval

By August 03, 2017

Sirukumab, a human monoclonal IgG1 kappa antibody, works differently than current IL-6 inhibitors approved to treat RA by targeting the IL-6 cytokine vs. the IL-6 receptor.

Xatmep Now Available for Pediatric ALL, pJIA

By July 31, 2017

Methotrexate works by inhibiting dihydrofolic acid reductase, which interferes with DNA synthesis, repair, and cellular replication.

Septic Arthritis Outbreak Highlights Need for Better Infection Prevention in Outpatient Settings

By July 27, 2017

Recovered organisms included various Streptococcus, Actinomyces, Haemophilus, Neisseria species, among others; all of the pathogens isolated were oral flora. Two patients also exhibited Staphylococcus aureus bacteria in the blood.

Morphine Effects Examined in RA, Chronic Fatigue Syndrome/Fibromyalgia

July 27, 2017

Anti-hyperalgesic effects of morphine also similar to placebo in chronic fatigue/fibromyalgia

Biosimilar Renflexis Now Available

July 24, 2017

Infliximab products work by neutralizing the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibiting the binding of TNF-alpha with its receptors.

Alendronate May Lower Hip Fracture Risk for Patients on Oral Glucocorticoids

By July 13, 2017

Results showed that after a mean follow-up of 1.32 years, there were 27 hip fractures in the alendronate group and 73 in the non-alendronate group; this corresponded to incident rates of 9.5 (95% CI, 6.5-13.9) and 27.2 (95% CI, 21.6-34.2) fractures per 1000 person-years, respectively.

Shock Wave Therapy Assessed for Efficacy in Arthritis, Arthralgia

July 10, 2017

"To our knowledge, this is the first report using this therapy to treat arthralgia in rheumatoid arthritis," the authors write.

Orencia Approved to Treat Active Psoriatic Arthritis

By July 06, 2017

A greater response to Orencia was observed in the trial regardless of prior anti-TNF treatment and other non-biologic DMARD therapy.

Rituxan Biosimilar BLA Accepted for FDA Review

By June 29, 2017

The proposed indications are for the treatment of non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), granulomatosis with polyangiitis and microscopic polyangiitis.

Case: Hand Transplant Patient Develops Rheumatoid Arthritis

June 28, 2017

"To our knowledge, this is the first report of rheumatoid arthritis in a hand transplant recipient," the authors write. "Whether it constitutes an atypical transplant rejection is unclear."

Fish Consumption and RA Symptoms: What's the Link?

June 26, 2017

Researchers suggest most varieties of fish may play a role in controlling symptoms

Intensive Use of Hand-Held Devices May Up Carpal Tunnel Risk

June 26, 2017

The researchers found that intensive electronics users had significantly more discomfort, and more severe discomfort, in their wrist and hand.

Anti-TNF-α Evaluated for Sleep Quality Effects in Ankylosing Spondylitis

June 23, 2017

The researchers found that 57.9% of all patients had impaired SQ in baseline evaluation. Obstructive apnea syndrome, snoring, and periodic leg movements were seen with PSG in 73.7, 74.4, and 26.3% of patients, respectively.

Upadacitinib Meets Endpoints for Phase 3 Study in RA

By June 23, 2017

The results from the 12-week period show that both arms of upadacitinib treatment were superior in achieving ACR 20 (64% in 15mg arm, 66% in 30mg arm) vs. placebo (36%).

Opioid Use Patterns Among RA Patients Examined

By June 21, 2017

The authors concluded that "rheumatologists and other clinicians caring for patients with RA face a significant dilemma precisely because the options for care of pain remain problematic."

Guidelines Address Peri-Op Management of Antirheumatic Drugs

June 21, 2017

The guidelines address perioperative use of antirheumatic drug therapy for adults with rheumatoid arthritis, spondyloarthritis, juvenile idiopathic arthritis, or systemic lupus erythematosus undergoing elective THA or TKA.

First-in-Class Drug Candidate Fast Tracked for Chronic Pain

By June 14, 2017

Currently, there is a global Phase 3 program comprised of 6 studies involving approximately 7,000 patients with OA, CLBP or cancer pain with inadequate treatment of pain with approved therapies.

Vitamin D, Omega-3s May Boost DMARD Response in Early RA

By June 12, 2017

The researchers aimed to evaluate the association between dietary vitamin D, omega-3 fatty acids, and treatment outcomes with DMARDs in patients with rheumatoid arthritis.

FDA Approves New Administration Option for Orencia in pJIA

By June 08, 2017

The approval of the prefilled syringe was based on dosing, efficacy, and safety data of SC abatacept in JIA among patients aged 2-17 years with inadequate response to at least one nonbiologic or biologic DMARD (Study JIA-2).

RA Drug Linked to Severe Skin Reaction in Patient with Adult-Onset Still Disease

June 01, 2017

Diffuse, persistent, pruritic maculopapular rash developed 10 days after tocilizumab treatment

Ixekizumab Beneficial in Psoriatic Arthritis Refractory to TNFi

May 31, 2017

Two-week and four-week ixekizumab dosing regimens improved signs and symptoms

Cost-Effectiveness of First-Line RA Strategies Compared

May 31, 2017

First-line etanercept-methotrexate would result in 0.15 additional lifetime QALY, at cost of 77,290

This Spice May Help Osteoarthritis Knee Pain

May 26, 2017

he researchers found that curcuminoids correlated with significantly reduced knee pain and improved quality of life.

High Fiber Diet, Chondroitin Evaluated for OA Knee Pain

May 25, 2017

In a study of 1,268 individuals it was found that for those who ate the most fiber, the risk was 61% less than those who ate the least fiber.

Kevzara Available for the Treatment of Rheumatoid Arthritis

By May 23, 2017

Kevzara (sarilumab) injection has been approved for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs.

Giant Cell Arteritis Treatment Gets FDA Approval

By May 22, 2017

In the study, Actemra given weekly and bi-weekly combined with a 6-month glucocorticoid regimen, more effectively sustained remission through Week 52 than placebo combined with a 26-week steroid taper and a 52-week steroid taper.