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AROMASIN
Breast cancer
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Drug Name:

AROMASIN Rx

Generic Name and Formulations:
Exemestane 25mg; tabs.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

Indications for AROMASIN:

In postmenopausal women: adjuvant treatment of estrogen-receptor positive early breast cancer after 2–3 years of tamoxifen therapy to complete a total of 5 years of hormonal therapy; advanced breast cancer with disease progression after tamoxifen therapy.

Adult Dose for AROMASIN:

Give after a meal. 25mg once daily. Concomitant potent CYP3A4 inducer (eg, rifampicin, phenytoin): 50mg once daily. Advanced disease: continue until tumor progression is evident.

Children's Dose for AROMASIN:

Not established.

Pharmacological Class:

Aromatase inactivator.

Contraindications:

Pregnancy (Cat.X). Premenopausal women.

Warnings/Precautions:

Hepatic or renal insufficiency. Perform routine assessment of Vit. D levels prior to initiation; supplement if deficient. Nursing mothers.

Interactions:

May be antagonized by estrogens (avoid), CYP3A4 inducers. Avoid concomitant bisphosphonates, Vit. D supplements, calcium.

Adverse Reactions:

Hot flashes, fatigue, arthralgia, headache, insomnia, increased sweating, nausea, increased appetite; reductions in bone mineral density.

How Supplied:

Tabs—30