ARALEN Rx

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ARALEN

Malaria
Protozoal infections
Only 4 drugs may be compared at once

Generic Name and Formulations:

Chloroquine phosphate 500mg; tabs.

Company:

Sanofi Aventis

Select therapeutic use:

Indications for ARALEN:

Suppression and treatment for acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum.

Adult:

Suppression: 500mg once every 7 days. Treatment: 1g once, then 500mg 6–8hrs later; then 500mg once daily for next 2 days. Low body wt: use children's dose.

Children:

Suppression: 8.35mg/kg (max 500mg) once every 7 days. Treatment: 16.7mg/kg (max 1g) once, then 8.35mg/kg (max 500mg) 6, 24 and 36hrs after 1st dose.

Contraindications:

Retinal or visual field changes.

Warnings/Precautions:

Suppression: start 2 weeks before and continue for 8 weeks after trip. Hepatic or auditory dysfunction. Alcoholism. Psoriasis. Porphyria. Seizure disorders. G6PD deficiency. Acute extrapyramidal disorders. Discontinue if hematologic, visual disorders or ototoxicity occurs. Monitor CBC, reflexes, vision in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.

Interactions:

Avoid cimetidine. Separate ampicillin dose by 2hrs; dosing of antacids, kaolin by 4hrs. Potentiates cyclosporine (monitor). Caution with hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine.

Pharmacological Class:

Aminoquinoline.

Adverse Reactions:

Retinopathy, maculopathy, macular degeneration, headache, pruritus, photosensitivity, GI (eg, hepatitis, anorexia, nausea, diarrhea, abdominal cramps) or CNS disturbances (eg, seizures, psychosis, tinnitus, visual changes), blood dyscrasias, neuromyopathy, cardiomyopathy.

How Supplied:

Tabs—25

ARALEN 500mg tablets (Qty:10)

appx. price $72.00

Indications for ARALEN:

Extraintestinal amebiasis (use with intestinal amebicide).

Adult:

1g daily for 2 days, then 500mg daily for at least 2–3 weeks.

Children:

See full labeling.

Contraindications:

Retinal or visual field changes.

Warnings/Precautions:

Suppression: start 2 weeks before and continue for 8 weeks after trip. Hepatic or auditory dysfunction. Alcoholism. Psoriasis. Porphyria. Seizure disorders. G6PD deficiency. Acute extrapyramidal disorders. Discontinue if hematologic, visual disorders or ototoxicity occurs. Monitor CBC, reflexes, vision in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.

Interactions:

Avoid cimetidine. Separate ampicillin dose by 2hrs; dosing of antacids, kaolin by 4hrs. Potentiates cyclosporine (monitor). Caution with hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine.

Pharmacological Class:

Aminoquinoline.

Adverse Reactions:

Retinopathy, maculopathy, macular degeneration, headache, pruritus, photosensitivity, GI (eg, hepatitis, anorexia, nausea, diarrhea, abdominal cramps) or CNS disturbances (eg, seizures, psychosis, tinnitus, visual changes), blood dyscrasias, neuromyopathy, cardiomyopathy.

How Supplied:

Tabs—25

ARALEN 500mg tablets (Qty:10)

appx. price $72.00