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MPR provides the right dose of information and gives you fast access to the most pertinent prescribing information you're looking for with interactive, expandable concise drug monographs
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PRINIVIL Rx Lisinopri l5mg, 10mg,
20mg; scored tabs.

Indications Heart failure inadequately controlled by diuretics +/or digitalis. Adjunct to other therapies within 24 hrs post-MI in hemodynamically stable patients, to reduce mortality. Adults CHF: initially 5mg once daily; range 5–20mg once daily; hyponatremia or moderate to severe renal impairment: initially 2.5mg once daily; supervise closely. Reduce diuretic dosage before 1st dose (if possible) and observe until BP is stabilized. Post-MI: 5mg within 24 hrs of onset of symptoms, then 5mg after 24 hrs, then 10mg after 48 hrs, then 10mg once daily for up to 6 weeks; if systolic BP ?120mmHg at onset, start with 2.5mg daily for 3 days; or if systolic BP ?100mmHg occurs, start with 5mg daily, then reduce to 2.5mg daily as needed; discontinue if prolonged hypotension (systolic BP ?90mmHg for >1 hr) occurs. Children Not recommended. Pharmacological ACE inhibitor. Contraindications History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes. Warnings/Precautions Fetal toxicity may develop; discontinue if pregnancy is detected. Renal impairment. Dialysis (esp. high-flux membrane). Salt/volume depletion. Hypertrophic cardiomyopathy. CHF. Ischemic heart disease. Cerebrovascular disease. Acute MI. Renal or aortic stenosis. Surgery. Monitor renal function, serum potassium in diabetics. Monitor WBCs in renal and collagen vascular disease patients. Discontinue if angioedema, laryngeal edema, marked elevations of liver enzymes, or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended. Interactions See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. May cause hypotension or increased BUN with diuretics. May cause hyperkalemia with K+ sparing diuretics, K+ supplements, or K+ -containing salt substitutes. May increase lithium levels; monitor frequently. Antagonized by, and increased risk of renal failure with, NSAIDs including selective COX-2 inhibitors. Hypoglycemia with oral antidiabetics, insulin. Nitritoid reactions with concomitant injectable gold (sodium aurothiomalate); rare. Adverse Reactions Dizziness, headache, fatigue, diarrhea, upper respiratory symptoms, cough, nausea, hyperkalemia, orthostatic hypotension, renal impairment, angioedema; liver dysfunction, blood dyscrasias (rare). Elimination Renal. Generic Availability YES How Supplied Tabs–90

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Tools

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