ANTIZOL Rx

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ANTIZOL

Poisoning/overdose
Only 4 drugs may be compared at once

Generic Name and Formulations:

Fomepizole 1g/mL; soln for IV infusion after dilution; preservative-free.

Select therapeutic use:

Indications for ANTIZOL:

Ethylene glycol or methanol poisoning; or suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.

Adult:

Give by slow IV infusion over 30mins. Loading dose of 15mg/kg, followed by 10mg/kg every 12hrs for 4 doses, then 15mg/kg every 12hrs until ethylene glycol or methanol concentration is <20mg/dL and patient is asymptomatic with normal pH. Hemodialysis: see literature.

Children:

Not recommended.

Contraindications:

Allergy to pyrazoles.

Warnings/Precautions:

Renal or hepatic impairment. Renal failure, significant or worsening metabolic acidosis, or high ethylene glycol or methanol concentrations (≥50mg/dL); consider hemodialysis in addition to fomepizole. Obtain blood gases, pH, electrolytes, liver enzymes, BUN, creatinine, urinalysis, ECG, WBCs frequently during therapy. Monitor serum and urine ethylene glycol concentrations and presence of urinary oxalate crystals; or serum methanol concentrations. Monitor for allergic reactions. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiates or potentiated by ethanol. May affect or be affected by CYP450 inducers/inhibitors (eg, phenytoin, carbamazepine, cimetidine, ketoconazole).

Pharmacological Class:

Alcohol dehydrogenase inhibitor.

Adverse Reactions:

Headache, nausea, dizziness, drowsiness, bad taste/metallic taste; rare: mild rash, eosinophilia.

How Supplied:

Vials (1.5mL)—4