Neostigmine Methylsulfate Injection, a cholinesterase inhibitor, is indicated to reverse the effects of non-depolarizing neuromuscular blockers after surgery.
The AMA will urge the Department of Health and Human Services and Department of Homeland Security to examine drug shortages as a national security initiative in response to hazards that pose a threat to the resilience of drug production.
The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.
Increased thirst and irritability are reported with prolonged fasting period, as well as detrimental physiological and metabolic effects. No increased risk of pulmonary aspiration was reported with a 1-hour clear fluid policy and studies demonstrated that the stomach was empty.
The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6%; etomidate + dexmedetomidine: 118.4 ± 39.1% of control).
The researchers found that liposomal bupivacaine was used in 21.2% of patients. Its use was not associated with a clinically meaningful reduction in inpatient opioid prescription, length of stay, or cost of hospitalization.
Atropine plus propofol similar to atropine plus atracurium and sufentanil for non-emergent intubation in neonates
In this randomized controlled trial, the frequency of prolonged desaturation during neonatal, nonemergent intubation was similar between atropine plus propofol compared to atropine plus atracurium and sufentanil.
More than 95% of respondents reported that the shortages had an impact on patient care. Hydromorphone, fentanyl, morphine, bupivacaine, and epinephrine were the top drugs listed in short supply.
The researchers found that those with multiple, but not single exposures, had an increased frequency of both learning disabilities and attention-deficit/hyperactivity disorder (hazard ratio for learning disabilities, 2.17) versus unexposed children.
Additionally, statistical significance vs placebo was also achieved in total postsurgical opioid consumption through 48 hours (P<0.0001); opioid-free subjects through 48 hours (P<0.01); and time to first opioid rescue through 48 hours (P<0.0001).
The researchers found that the ketamine-propofol group experienced significantly shorter recovery times; 38 versus 54 minutes; median difference, 14 minutes; P<0.001.
The primary outcome (composite of all-cause death, hospital readmission, or major postoperative complications within 30 postoperative days) occurred in 44 and 29% of the complete-handover and no-handover groups, respectively, in the unweighted sample.
The new Convenience Pack includes SuturaGel Methylcellulose Base, which is designed to reduce the amount of medication run-off from the treatment area.
The affected lots were distributed in the U.S, Dutch Antilles, Barbados, Canada, Philippines, Kuwait, and Singapore between January to June 2017.
In this study, researchers reviewed the evidence on the use of IN administration for several medications commonly used in the emergency department.
Since 1999, the FDA has been evaluating the potential adverse effects of general anesthetics and sedatives on children's brain development.
For patients undergoing transcatheter aortic valve replacement (TAVR), local anesthetic (LA) is as safe as general anesthetic (GA), with shorter procedure time and number of days in the hospital, according to a study published in The American Journal of Cardiology.
Exparel, an amide local anesthetic, is FDA approved for single-dose infiltration into the surgical site to produce postsurgical analgesia.
Children exposed to surgical anesthesia before the age of 4 may have slightly lower school grades and IQ scores in their late teen years, according to a study published online in JAMA Pediatrics.
Hospira announced a voluntary recall of 3 lots of Fentanyl Citrate Injection 50mcg/mL due to confirmed ampules with broken tips.
Few pediatric patients having a dental procedure combined with another surgical procedure require unplanned admission for perioperative concerns.
Electronic tablets such as iPads demonstrated similar efficacy as a sedative commonly administered to children before general anesthesia, a new study has found.