Anaphylaxis

FDA Announces New Drug Shortages Task Force

By July 12, 2018

Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Most Adults Don't Use Their Epinephrine Auto-Injectors During Reactions

By June 21, 2018

Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.

Intranasal Epinephrine for Anaphylaxis Looks Promising in Early Study

By June 14, 2018

The pharmacokinetics trial, which included 60 participants with seasonal allergies, also demonstrated rapid drug absorption with the intranasal spray.

Concerns Over EpiPen Supply Prompt Statement from Mylan

By May 09, 2018

Intermittent supply constraints due to manufacturing delays from Mylan's manufacturing partner, Meridian Medical Technologies, have resulted in varying supply levels.

Auvi-Q 0.1mg Auto-Injector Available Soon for Infants, Toddlers

By April 26, 2018

The supplemental New Drug Application (sNDA) for the 0.1mg strength was granted Priority Review by the Food and Drug Administration (FDA).

Pathway modification reduces admissions for pediatric anaphylaxis

April 11, 2018

Inpatient and observation unit admissions for pediatric anaphylaxis decreased by more than half following implementation of a revised clinical care pathway.

Death After Bee Venom Apitherapy in Previously Tolerant Patient

By March 21, 2018

In this case, a 55-year-old woman developed wheezing, dyspnea, and sudden loss of consciousness during her apitherapy session in which she received live bee stings to improve muscular contractures and stress.

Symjepi vs EpiPen: Incorrect Usage Rates Among Untrained Teens

By March 08, 2018

The study enrolled 34 adolescents aged 12 to 17 years old who had no familiarity with an epinephrine device (naive) and did not receive training during the study.

Peanut Allergy Oral Immunotherapy Effective in Phase 3 Study

By February 21, 2018

With regard to adverse events, 12.4% of AR101-treated patients discontinued treatment due to treatment-related side effects; these included gastrointestinal adverse events (6.7%) and systemic allergic hypersensitivity reactions (2.7%).

Survey: Most At-Risk Patients Don't Carry Two Epinephrine Auto-Injectors

By February 08, 2018

Most respondents did not carry 2 EAIs in order to keep 1 EAI in another location.

Varubi Labeling Updated to Warn of Serious Hypersensitivity Reactions

By January 16, 2018

Anaphylaxis, anaphylactic shock and other serious hypersensitivity reactions have been reported.

New Flu Vaccine Guidelines Issued for Patients With Egg Allergy

By December 19, 2017

The updated parameter stresses that no special precautions are needed or recommended for those with egg allergy.

Auvi-Q 0.1mg Auto-Injector Approved for Infants, Small Children

By November 20, 2017

Auvi-Q 0.1mg is the first epinephrine auto-injector specifically designed for the treatment of life-threatening allergic reactions, including anaphylaxis, in infants and small children weighing 16.5 to 33 pounds.

Researchers Develop Portable Food Allergen-Detection System

By September 07, 2017

Most products were accurate to their stated label, however most products did contain at least 1 unspecified antigen, for instance, "brand of nut-free cookies contained gluten, whereas a gluten-free brand contained a peanut allergen," the authors write.

Peanut Allergy Tx Efficacy Examined in 4-Year Follow-Up Study

By August 17, 2017

Results found that 4 children initially treated with PPOIT and 6 treated with placebo had allergic reactions to peanut intake, none experience prophylaxis.

FDA: Severe Hypersensitivity, Death Following Curcumin Injection

By August 04, 2017

In March and May 2017, two patients given intravenous (IV) infusions of curcumin emulsion compounded with polyethylene glycol (PEG) 40 castor oil reported having immediate hypersensitivity reactions.

Epinephrine Auto-Injector for Infants, Small Children Gets Priority Review

By July 27, 2017

The company has indicated that if the new auto-injector is approved they expect it to be available for patients in the first half of 2018.

Delayed Anaphylaxis Treatment Often Occurs in Children

July 13, 2017

The researchers found that 36.3% of the children received epinephrine before arrival at the emergency department or UCC.

Vitamin D Supplementation Assessed for Preventing Allergic Diseases

July 12, 2017

The researchers found that based on very low certainty in the body of evidence across examined studies, vitamin D supplementation may not reduce the risk of developing allergic diseases.

Recommendations Issued in Response to Hymenoptera Venom Extract Shortage

July 10, 2017

Facing expected season-long shortage, doctors asked to urge patients to carry epinephrine auto-injectors

Symjepi Approved for Emergency Anaphylaxis Treatment

By June 16, 2017

Symjepi should only be injected into the anterolateral aspect of the thigh; injection into other areas such as the buttocks or the hands and feet may result in adverse effects and may also not provide effective treatment of anaphylaxis.

Quality of Life May Drop for Some During Oral Immunotherapy

May 30, 2017

Patients with better QOL at baseline, might deteriorate after therapy

Delayed Allergic Reaction Triggered by Meat Linked to Tick Bites

By May 24, 2017

States in the Midwest and South appear to have the highest prevalence of both alpha-gal allergy and rickettsial diseases transmitted by the Lone Star tick or Amblyomma americanum.

Case: Exercise-Induced Anaphylaxis After Shrimp Consumption

May 17, 2017

FDEIA due to shrimp consumption reported in 18-year-old with specific IgE antibodies against 43 kDa

Are Expired EpiPens Still Effective?

May 10, 2017

Patients at a community clinic in San Diego were asked to bring in unused, expired EpiPens so they could be examined.

Potential Defect Prompts EpiPen Recall

By April 03, 2017

The recall affects both the EpiPen Auto-Injector 0.15mg and 0.3mg strengths and the product was distributed by Mylan Specialty between December 2015 and July 2016.

Refractory Ulcerative Colitis in a Patient with NSAID Hypersensitivity

By March 22, 2017

The patient, a 33-year old woman with a history of drug hypersensitivity to NSAIDs and aspirin, presented for management of her chronic UC with mesalamine.

AAP: Epinephrine Auto-Injector, Action Plan Crucial for Anaphylaxis Management

February 14, 2017

This clinical report from the American Academy of Pediatrics is an update on their 2007 clinical report.

FDA: Life-Threatening Allergic Reactions Linked to Skin Antiseptic

By February 02, 2017

Reactions can occur within minutes of exposure.

Voice-Guided Epinephrine Auto-Injector Soon to Be Available

By January 19, 2017

Kaléo announced that Auvi-Q (epinephrine injection) Auto-injector will be available in pharmacies beginning February 14th.