ANAFRANIL

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Generic Name for ANAFRANIL

Clomipramine HCl 25mg, 50mg, 75mg; caps.

Legal Classification:

Rx

Pharmacological Class for ANAFRANIL

Tricyclic.

Manufacturer of ANAFRANIL

Mallinckrodt, Inc.

Indications for ANAFRANIL

Obsessive-compulsive disorder.

Adult dose for ANAFRANIL

Take with food. Initially 25mg/day; titrate to 100mg/day in divided doses in first 2 weeks. Adjust as needed; max 250mg/day. May give total daily maintenance dose at bedtime.

Children's dosing for ANAFRANIL

<10 yrs: not recommended. Others: initially with food 25mg/day. Increase gradually over first 2 wks to 3mg/kg per day or 100mg/day (in divided doses) whichever is smaller. Further increases as needed to 3mg/kg per day or 200mg/day whichever is smaller. After titration, total daily dose may be given at bedtime.

Contraindications for ANAFRANIL

During or within 14 days of MAOIs. Acute post-MI.

Warnings/Precautions for ANAFRANIL

Glaucoma. Adrenal tumors. Urinary retention. Suicidal tendencies. Cardiovascular disease. Epilepsy or other seizure risk. Psychosis. Mania/hypomania. Bipolar disorder. Hepatic or renal dysfunction. Hyperthyroidism. ECT. Surgery. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions for ANAFRANIL

See Contraindications. Hyperpyretic crisis, seizures, coma and death with MAOIs. Potentiates alcohol, other CNS depressants, anticholinergics, sympathomimetics, other protein-bound drugs. Potentiated by CYP2D6 and/or CYP1A2 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin, other CYP450 inducers. Caution with drugs that lower seizure threshold. Blocks guanethidine, clonidine.

Adverse Reactions for ANAFRANIL

Seizures, male sexual dysfunction, hyperthermia, anticholinergic effects, nausea, dyspepsia, anorexia, somnolence, dizziness, nervousness, changed libido, weight gain, visual changes, blood dyscrasias, neuropsychiatric disturbances.

How is ANAFRANIL supplied?

Caps—100

Related Disease:

Obsessive-compulsive disorder

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