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AMTURNIDE
Hypertension
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Drug Name:

AMTURNIDE Rx

AMTURNIDE (aliskiren/amlodipine/hydrochlorothiazide) tablets by Novartis

Generic Name and Formulations:
Aliskiren hemifumarate/amlodipine besylate/hydrochlorothiazide (HCTZ); 150/5/12.5mg; 300/5/12.5mg; 300/5/25mg; 300/10/12.5mg; 300/10/25mg; tablets.

Company:
Novartis Pharmaceuticals Corp

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for AMTURNIDE:

Hypertension. Not for initial therapy.

Adult Dose for AMTURNIDE:

Take once daily. Titrate at 2-week intervals; max one 300/10/25mg tablet daily. Replacement: may substitute for individually titrated components. Add-on/switch: if not adequately controlled on any two of the following: aliskiren, dihydropyridine CCB, thiazide diuretics. May switch with a lower dose of any component that causes dose-limiting ADRs. ≥75 years or severe hepatic impairment: initially amlodipine 2.5mg/day (not available). Concomitant simvastatin: see Interactions.

Children's Dose for AMTURNIDE:

Not recommended.

Pharmacological Class:

Renin inhibitor + dihydropyridine calcium channel blocker (CCB) + thiazide diuretic.

Contraindications:

Concomitant ARBs or ACEIs in diabetes. Anuria. Sulfonamide allergy.

Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting or start under close supervision. Severe obstructive coronary disease: increased risk of angina or MI with CCB dose change. Moderate renal dysfunction (CrCl <60mL/min): avoid concomitant with ARBs or ACEIs. Impaired renal function: monitor serum creatinine periodically. Renal artery stenosis. Heart failure. Monitor for electrolyte disturbances. Hepatic dysfunction. Asthma. SLE. Gout. Acute myopia. Secondary angle-closure glaucoma. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.

Interactions:

Aliskiren: concomitant cyclosporine, itraconazole: not recommended. Caution with ACEIs, ARBs, NSAIDs, K+ sparing diuretics, K+ containing salt substitutes; may cause hyperkalemia. Decreased absorption with high fat meals. HCTZ: concomitant lithium (risk of toxicity): monitor; potentiates antihypertensives, possibly non-depolarizing muscle relaxants; orthostatic hypotension with alcohol, other CNS depressants; may need to adjust antidiabetic agents; decreased absorption by cholestyramine, colestipol resins (separate dosing by at least 4 hours). Both Aliskiren + HCTZ: may be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Amlodipine potentiates simvastatin; limit simvastatin dose to max 20mg daily.

Adverse Reactions:

Peripheral edema, dizziness, headache, nasopharyngitis; rare: angioedema (discontinue if occurs, do not restart).

How Supplied:

Tabs—30, 90, 100