Select therapeutic use:
Indications for AMPYRA:
To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed).
Swallow whole. ≥18yrs: max 10mg every 12 hours.
<18yrs: not established.
History of seizures. Moderate to severe renal impairment (CrCl ≤50mL/min). Previous allergies to 4-aminopyridine.
Assess renal function before initiation; monitor at least annually. Mild renal impairment (CrCl 51–80mL/min): increased risk of seizures. Discontinue if signs/symptoms of anaphylaxis occurs. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Concomitant other forms of 4-aminopyridine; discontinue prior to initiating.
Potassium channel blocker.
UTI, insomnia, dizziness, headache, nausea, asthenia, back pain, balance disorder, MS relapse, paresthesia, nasopharyngitis, constipation, dyspepsia, throat pain; seizures (possible at higher doses), severe allergic reactions.