Susceptible infections including ear/nose/throat (ENT), genitourinary tract, skin and skin structures, lower respiratory, acute uncomplicated gonorrhea.
>40kg: ENT: mild/moderate: 500mg every 12hrs; severe: 875mg every 12hrs. Lower respiratory tract: 875mg every 12hrs. Skin/skin structure: mild/moderate: 500mg every 12hrs; severe: 875mg every 12hrs. Genitourinary tract: mild/moderate: 500mg every 12hrs; severe: 875mg every 12hrs. Gonorrhea, acute uncomplicated ano-genital and urethral infections: 3g as single oral dose.
≤3 months: max 30mg/kg per day in 2 divided doses every 12 hrs. >3 months (<40kg): ENT, genitourinary, skin: 25mg/kg/day in divided doses every 12hrs. Severe infections, or lower respiratory infections: 45mg/kg/day in divided doses every 12hrs. Gonorrhea: <2 yrs: not recommended; prepubertal: amoxicillin 50mg/kg + probenecid 25mg/kg as a single dose.
Cephalosporin, imipenem or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Serum levels increased by probenecid.
GI upset, hypersensitivity reactions (e.g., urticaria, rash, Stevens-Johnson syndrome, anaphylaxis), hyperactivity, blood dyscrasias.
Formerly known under the brand names Amoxil, Trimox, Ultimox, Wymox (caps, susp), Polymox (susp).