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AMITIZA
Colorectal disorders
Constipation and bowel cleansers
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Drug Name:

AMITIZA Rx

Generic Name and Formulations:
Lubiprostone 8mcg, 24mcg; caps.

Company:
Sucampo and Takeda

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for AMITIZA:

Irritable bowel syndrome with constipation (IBS–C) in women.

Adult Dose for AMITIZA:

Swallow whole. Take with food and water. ≥18yrs: 8mcg twice daily. Severe hepatic impairment (Child-Pugh Class C): 8mcg once daily.

Children's Dose for AMITIZA:

<18yrs: not recommended.

Pharmacological Class:

GI motility enhancer (chloride channel activator).

Contraindications:

Known or suspected mechanical GI obstruction.

Warnings/Precautions:

Confirm absence of GI obstruction before starting therapy. Severe diarrhea: not recommended. Renal or hepatic impairment. Reevaluate periodically. Pregnancy (Cat.C). Nursing mothers; monitor infants for diarrhea.

Interactions:

Possibly antagonized by diphenylheptane opioids (eg, methadone).

Adverse Reactions:

Nausea, headache, diarrhea (suspend therapy if occurs), abdominal pain, abdominal distension, flatulence, dyspnea, vomiting, syncope, asthenia, others.

Elimination:

Renal (primary), fecal.

How Supplied:

8mcg—60; 24mcg—60, 100

AMITIZA

  • 24mcg capsules (Qty:30)
  • appx. price $167.00
GoodRx

Indications for AMITIZA:

Chronic idiopathic constipation. Opioid-induced constipation (OIC) in adults with chronic non-cancer pain. Limitations of use: effectiveness of Amitiza in the treatment of OIC in patients taking diphenylheptane opioids (eg, methadone) has not been established.

Adult Dose for AMITIZA:

Swallow whole. Take with food and water. 24mcg twice daily. Moderate hepatic impairment (Child-Pugh Class B): 16mcg twice daily. Severe hepatic impairment (Child-Pugh Class C): 8mcg twice daily.

Children's Dose for AMITIZA:

Not recommended.

Pharmacological Class:

GI motility enhancer (chloride channel activator).

Contraindications:

Known or suspected mechanical GI obstruction.

Warnings/Precautions:

Confirm absence of GI obstruction before starting therapy. Severe diarrhea: not recommended. Renal or hepatic impairment. Reevaluate periodically. Pregnancy (Cat.C). Nursing mothers; monitor infants for diarrhea.

Interactions:

Possibly antagonized by diphenylheptane opioids (eg, methadone).

Adverse Reactions:

Nausea, headache, diarrhea (suspend therapy if occurs), abdominal pain, abdominal distension, flatulence, dyspnea, vomiting, syncope, asthenia, others.

Elimination:

Renal (primary), fecal.

How Supplied:

8mcg—60; 24mcg—60, 100

AMITIZA

  • 24mcg capsules (Qty:30)
  • appx. price $167.00
GoodRx

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