Amiloride/HCTZ Rx

Indications for Amiloride/HCTZ:

Edema when normokalemia is important.

Adult Dose for Amiloride/HCTZ:

Initially 1 tab daily with food; may increase to 2 tabs daily in single or divided doses. After initial diuresis, reassess therapy; may be given intermittently for maintenance.

Children's Dose for Amiloride/HCTZ:

Not recommended.

Pharmacological Class:

K⁺-sparing + thiazide.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K⁺ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K⁺-sparing diuretics, K⁺ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.

Adverse Reactions:

Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.

Note:

Formerly known under the brand name Moduretic.

How Supplied:

Contact supplier.

Indications for Amiloride/HCTZ:

Hypertension when normokalemia is important.

Adult Dose for Amiloride/HCTZ:

Initially 1 tab daily with food. May increase to 2 tabs daily in single or divided doses.

Children's Dose for Amiloride/HCTZ:

Not recommended.

Pharmacological Class:

Diuretic combination.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K⁺ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K⁺-sparing diuretics, K⁺ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.

Adverse Reactions:

Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.

Note:

Formerly known under the brand name Moduretic.

How Supplied:

Contact supplier.