Amiloride/HCTZ Rx

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Amiloride/HCTZ

Edema
Hypertension
Only 4 drugs may be compared at once

Generic Name and Formulations:

Amiloride HCl 5mg, hydrochlorothiazide 50mg; scored tabs.

Select therapeutic use:

Indications for Amiloride/HCTZ:

Edema when normokalemia is important.

Adult:

Initially 1 tab daily with food; may increase to 2 tabs daily in single or divided doses. After initial diuresis, reassess therapy; may be given intermittently for maintenance.

Children:

Not recommended.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.

Note:

Formerly known under the brand name Moduretic.

How Supplied:

Contact supplier.

Indications for Amiloride/HCTZ:

Hypertension when normokalemia is important.

Adult:

Initially 1 tab daily with food. May increase to 2 tabs daily in single or divided doses.

Children:

Not recommended.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.

Note:

Formerly known under the brand name Moduretic.

How Supplied:

Contact supplier.