Amiloride

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Generic Name for Amiloride

Amiloride HCl 5mg; tabs.

Legal Classification:

Rx

Pharmacological Class for Amiloride

Diuretic (K+ sparing).

Manufacturer of Amiloride

Various generic manufacturers

Indications for Amiloride

Adjunct in hypertension.

Adult dose for Amiloride

Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring.

Children's dosing for Amiloride

Not recommended.

Contraindications for Amiloride

Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.

Warnings/Precautions for Amiloride

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions for Amiloride

Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.

Adverse Reactions for Amiloride

Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.

How is Amiloride supplied?

Contact supplier.

Related Disease:

Hypertension

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