AMBIEN CIV

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AMBIEN

Sleep-wake disorders
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Generic Name and Formulations:

Zolpidem tartrate 5mg, 10mg; tabs.

Company:

Sanofi Aventis

Select therapeutic use:

Indications for AMBIEN:

Insomnia.

Adult:

Use lowest effective dose. Initially 5mg (in women), and 5mg or 10mg (in men) at bedtime (take only if able to get 7–8hrs of sleep before becoming active again). Both: if 5mg dose ineffective, may increase to max 10mg. Elderly, debilitated, or mild-to-moderate hepatic impairment: 5mg once daily at bedtime. Effect delayed if taken with a meal.

Children:

<18yrs: not recommended.

Warnings/Precautions:

Increased risk of next-day psychomotor impairment. Depression. Abnormal thinking and behavioral changes. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Avoid in severe hepatic impairment; may contribute to encephalopathy. Evaluate for co-morbid diagnoses before initiation. Reevaluate if insomnia persists after 7–10 days of use. Drug or alcohol abuse. Write ℞ for smallest practical amount. Withdraw gradually. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Concomitant other sedative-hypnotics including other zolpidem products: not recommended. Increased risk of CNS depression, drowsiness, psychomotor impairment with alcohol, other CNS depressants (eg, benzodiazepines, opioids, tricyclics). May be potentiated by CYP3A4 inhibitors (eg, ketoconazole), sertraline. Decreased alertness with imipramine, chlorpromazine. May be antagonized by CYP3A4 inducers (eg, rifampin).

See Also:

AMBIEN CR

Pharmacological Class:

Imidazopyridine hypnotic.

Adverse Reactions:

CNS effects, complex sleep-related behaviors (eg, sleep-driving), headache, next-day somnolence, drowsiness, dizziness, diarrhea, dry mouth; anaphylaxis, angioedema.

How Supplied:

CR tabs 6.25mg—100; 12.5mg—100, 500; tabs 5mg—100; 10mg—100, 500

AMBIEN 10mg tablets (Qty:30)

appx. price $493.00