Alzheimer's Dementia

Model Projects Alzheimer's Disease to Double in U.S. by 2060

December 08, 2017

A differential impact is anticipated for primary and secondary preventions on future disease burden.

New Study Sheds Light on Safety of Gadolinium-Based Contrast Agents

By November 29, 2017

After adjusting for gender, age, education level, baseline neurocognitive performance, and others, the authors reported gadolinium exposure was not a significant predictor of cognitive decline, dementia, diminished neuropsychological performance or diminished motor performance

Anticholinergic Scoring Systems Appraised in Clinical Settings

November 28, 2017

The researchers found that the ACB showed the strongest and most consistent dose-response relationships with risks of all four adverse outcomes compared with ARS and DBI-Ach, especially among those aged 65 to 84 years.

New Immunoassays Show Improvement in Measuring Aβ42 in CSF

November 09, 2017

The researchers found that the mass spectrometry-derived Aβ42 values showed higher correlations with the modified Aβ42-INNOTEST, Aβ42-FL, Aβ42-EI, and Aβ42-MSD assays versus the classic Aβ42-INNOTEST assay.

FDA Grants Alzheimer's Disease Drug Candidate Fast Track Status

By October 25, 2017

The company said in a press release that their pivotal Phase 3 program for ALZ-801 will focus on approval in the genetically-defined subpopulation of high risk patients who are at the Mild stage of AD.

First-in-Class Alzheimer's Drug Gets Fast-Tracked by FDA

By October 16, 2017

CT1812 is a first-in-class, orally-administered small molecule that targets the sigma-2 receptor complex on neuronal synapses, displacing beta amyloid oligomers from their binding sites on brain cells and clearing them in to the cerebrospinal fluid.

No Significant Improvement with Intepirdine in Alzheimer's Disease Study

By September 26, 2017

The study included patients with mild to moderate Alzheimer's disease on donepezil therapy (n= 1315) and compared once-daily oral doses of intepirdine 35mg to placebo over 24 weeks.

High Systolic BP Linked to Negative Cognitive Outcomes

August 23, 2017

Researchers find that healthy reductions may benefit blacks even more than whites

Memantine Started Quickly After TBI May Reduce Levels of Brain Damage Biomarker

By August 04, 2017

Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng/mL for the control group (P=0.05).

Dementia Risk Up in Older Patients with Hearing Loss

July 31, 2017

The researchers found that in cross-sectional analyses, participants with self-reported or objective moderate and poor hearing were more likely to have a dementia diagnosis than those with normal hearing, after adjustment for potential confounders.

Is Fasting Plasma Glucose a Predictor of Alzheimer's in T2D?

July 25, 2017

Both FPG CV and HbA1c CV were significant predictors of AD after adjustment for sociodemographic factors, lifestyle behaviors, diabetes-related variables, FPG and HbA1c, drug-related variables, and comorbidities.

Targeting These 9 Factors May Help Prevent Dementia, Say Experts

July 21, 2017

Addressing these risk factors could help prevent 35 percent of dementia cases, researchers suggest

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

The Puzzles That May Improve Brain Performance

July 18, 2017

"We found direct relationships between the frequency of word puzzle use and the speed and accuracy of performance on nine cognitive tasks assessing a range of aspects of function including attention, reasoning, and memory," researcher Keith Wesnes, PhD.

Certain Diets Linked to Improved Cognitive Function in Older Adults

July 10, 2017

The researchers found that in fully adjusted models, participants with mid and high MedDiet scores were less likely to have poor cognitive performance than those with low scores.

More Sleep May Help Stave off Alzheimer's in Those At Risk

July 07, 2017

The researchers found an association between greater AD pathology and worse subjective sleep quality, more sleep problems, and daytime somnolence.

Is Chocolate the New 'Brain Food'?

By June 29, 2017

"Collectively, these findings seem to support quite consolidated epidemiological evidence indicating that regular cocoa flavanols intake possesses the potential to protect human cognition, particularly in aged populations," write the authors.

Study Examines Link Between PPI Use and Alzheimer's Disease

June 29, 2017

"PPIs were not associated with greater risk of dementia or of Alzheimer's disease, in contrast to recent reports. Study limitations include reliance on self-reported PPI use and lack of dispensing data," the authors write.

Do PPIs Increase the Risk of Dementia?

By June 22, 2017

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

FDA Fast Tracks Drug for Hallucinations Disorder in Lewy Body Dementia

By June 19, 2017

Nelotanserin is a novel once-daily oral 5HT2A inverse agonist. The 5HT2A receptor has been associated with neuropsychiatric effects, including visual hallucinations.

Delaying Anticoagulation Tx in Afib May Increase Dementia Risk

May 15, 2017

Even patients with a low risk of stroke could benefit, researchers say

Does Low BMI Have a Causal Effect on Alzheimer's Disease?

May 10, 2017

The scientists did find a relationship between gene variants associated with having a high BMI and type 2 diabetes, but there was no such connection in terms of Alzheimer's.

Low-Dose Aspirin Assessed for Cognitive Decline Protection

May 09, 2017

Over a median of 6 years of follow-up, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

Gene Mutation Linked to Faster Decline in Alzheimer's Patients

May 04, 2017

Researchers said the gene mutation - called BDNF Val66Met allele, or the Met allele - was pinpointed by following 1,023 people who were at risk of developing Alzheimer's disease.

Brexpiprazole Evaluated for Agitation in Alzheimer's Dementia

May 03, 2017

Otsuka and Lundbeck announced top-line results from two Phase 3 trials of brexpiprazole for the treatment of agitation in patients with dementia of the Alzheimer's type.

Undetected Seizures May Intensify Alzheimer's Pathology

May 03, 2017

One of the women experienced 3 seizures during a 12-hour period, with none producing any visible symptoms.

Serious Health Risks Linked to Artificially Sweetened Beverages

April 21, 2017

Analysis found that a higher recent and cumulative intake of artificially-sweetened soft drinks correlated with increased risk of ischemic stroke, all-cause dementia, and Alzheimer's disease dementia.

Communication Training May Help Cut Nursing Home Antipsychotic Use

April 21, 2017

Researchers found that nursing homes enrolled in the OASIS program had a 7.6% drop in antipsychotic prescriptions, compared with a 3.9% decline at the other nursing homes.

Does Low-Dose Aspirin Protect Against Cognitive Decline?

By April 20, 2017

The analysis showed that over a median of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

Tolerability, Adherence to Alzheimer's Drugs Assessed

By April 11, 2017

Overall, the researchers found no variation in tolerability or adherence to the 3 medications based on gender, race, education or age.