Alzheimer's Dementia

Memantine Started Quickly After TBI May Reduce Levels of Brain Damage Biomarker

By August 04, 2017

Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng/mL for the control group (P=0.05).

Dementia Risk Up in Older Patients with Hearing Loss

July 31, 2017

The researchers found that in cross-sectional analyses, participants with self-reported or objective moderate and poor hearing were more likely to have a dementia diagnosis than those with normal hearing, after adjustment for potential confounders.

Is Fasting Plasma Glucose a Predictor of Alzheimer's in T2D?

July 25, 2017

Both FPG CV and HbA1c CV were significant predictors of AD after adjustment for sociodemographic factors, lifestyle behaviors, diabetes-related variables, FPG and HbA1c, drug-related variables, and comorbidities.

Targeting These 9 Factors May Help Prevent Dementia, Say Experts

July 21, 2017

Addressing these risk factors could help prevent 35 percent of dementia cases, researchers suggest

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

The Puzzles That May Improve Brain Performance

July 18, 2017

"We found direct relationships between the frequency of word puzzle use and the speed and accuracy of performance on nine cognitive tasks assessing a range of aspects of function including attention, reasoning, and memory," researcher Keith Wesnes, PhD.

Certain Diets Linked to Improved Cognitive Function in Older Adults

July 10, 2017

The researchers found that in fully adjusted models, participants with mid and high MedDiet scores were less likely to have poor cognitive performance than those with low scores.

More Sleep May Help Stave off Alzheimer's in Those At Risk

July 07, 2017

The researchers found an association between greater AD pathology and worse subjective sleep quality, more sleep problems, and daytime somnolence.

Is Chocolate the New 'Brain Food'?

By June 29, 2017

"Collectively, these findings seem to support quite consolidated epidemiological evidence indicating that regular cocoa flavanols intake possesses the potential to protect human cognition, particularly in aged populations," write the authors.

Study Examines Link Between PPI Use and Alzheimer's Disease

June 29, 2017

"PPIs were not associated with greater risk of dementia or of Alzheimer's disease, in contrast to recent reports. Study limitations include reliance on self-reported PPI use and lack of dispensing data," the authors write.

Do PPIs Increase the Risk of Dementia?

By June 22, 2017

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

FDA Fast Tracks Drug for Hallucinations Disorder in Lewy Body Dementia

By June 19, 2017

Nelotanserin is a novel once-daily oral 5HT2A inverse agonist. The 5HT2A receptor has been associated with neuropsychiatric effects, including visual hallucinations.

Delaying Anticoagulation Tx in Afib May Increase Dementia Risk

May 15, 2017

Even patients with a low risk of stroke could benefit, researchers say

Does Low BMI Have a Causal Effect on Alzheimer's Disease?

May 10, 2017

The scientists did find a relationship between gene variants associated with having a high BMI and type 2 diabetes, but there was no such connection in terms of Alzheimer's.

Low-Dose Aspirin Assessed for Cognitive Decline Protection

May 09, 2017

Over a median of 6 years of follow-up, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

Gene Mutation Linked to Faster Decline in Alzheimer's Patients

May 04, 2017

Researchers said the gene mutation - called BDNF Val66Met allele, or the Met allele - was pinpointed by following 1,023 people who were at risk of developing Alzheimer's disease.

Brexpiprazole Evaluated for Agitation in Alzheimer's Dementia

May 03, 2017

Otsuka and Lundbeck announced top-line results from two Phase 3 trials of brexpiprazole for the treatment of agitation in patients with dementia of the Alzheimer's type.

Undetected Seizures May Intensify Alzheimer's Pathology

May 03, 2017

One of the women experienced 3 seizures during a 12-hour period, with none producing any visible symptoms.

Serious Health Risks Linked to Artificially Sweetened Beverages

April 21, 2017

Analysis found that a higher recent and cumulative intake of artificially-sweetened soft drinks correlated with increased risk of ischemic stroke, all-cause dementia, and Alzheimer's disease dementia.

Communication Training May Help Cut Nursing Home Antipsychotic Use

April 21, 2017

Researchers found that nursing homes enrolled in the OASIS program had a 7.6% drop in antipsychotic prescriptions, compared with a 3.9% decline at the other nursing homes.

Does Low-Dose Aspirin Protect Against Cognitive Decline?

By April 20, 2017

The analysis showed that over a median of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

Tolerability, Adherence to Alzheimer's Drugs Assessed

By April 11, 2017

Overall, the researchers found no variation in tolerability or adherence to the 3 medications based on gender, race, education or age.

Do Psychiatric Disorders Correlate With Future Risk of Alzheimer's?

April 11, 2017

We examined whether mental and behavioral disorders in general or specific mental and behavioral disorder categories increase the risk of Alzheimer's disease.

Insulin Resistance-, High Fasting Levels May Impact Cognition

April 10, 2017

The researchers found that higher baseline HOMA-IR and fasting insulin levels were independent predictors of poorer verbal fluency performance (P=0.0002 for both) and of a greater decline in verbal fluency over follow-up (P=0.004 for both).

Benzodiazepine Use Among Alzheimer's Patients May Up Pneumonia Risk

By April 10, 2017

Analysis found that the use of benzodiazepines was significantly associated with an increased risk of pneumonia (aHR 1.28, 95% CI: 1.07-1.54) but not for the similarly acting non-benzodiazepines (aHR 1.10, 95% CI: 0.84-1.44).

First Consumer Genetic Health Risk Tests Get FDA Approval

By April 06, 2017

While the GHR tests may provide genetic risk information, they cannot determine a person's overall risk for developing a disease, as other factors beyond genetics (ie, environment, lifestyle) may also influence risk.

Androgen Deprivation Tx and Dementia: Is There a Link?

By March 30, 2017

Researchers analyzed the outcome of dementia among prostate cancer patients exposed to ADT vs. a lesser-exposed comparison group.

PPI Use Significantly Increases Pneumonia Risk in Dementia

March 30, 2017

A retrospective cohort study looked at 786 patients with dementia and new PPI usage and 786 matched patients with dementia without PPI usage.

Orthostatic Hypotension and Dementia: What's the Link?

March 13, 2017

Middle-aged adults found 40 percent more likely to develop dementia over time

Ten Percent of U.S. Seniors Now Living with Alzheimer's

March 08, 2017

Alzheimer's is now the fifth leading cause of death among seniors; and the only disease among the nation's top 10 causes of mortality for which there is no prevention, no way to slow progression, and no cure.