ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ALTOPREV
Hyperlipoproteinemias
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ALTOPREV Rx

Generic Name and Formulations:
Lovastatin 20mg, 40mg, 60mg; ext-rel tabs.

Company:
Shionogi, Inc.



Therapeutic Use:

Indications for ALTOPREV:

To reduce risk of MI, unstable angina, and coronary revascularization procedures in patients without symptomatic cardiovascular disease (CVD), average to moderately elevated total-C and LDL-C, and below average HDL-C. Adjunct to diet in primary hypercholesterolemia and mixed dyslipidemias (Types IIa and IIb) to lower elevated total-C, LDL-C, apo B, and TG, and to increase HDL-C, when response to nondrug therapy alone is inadequate. To slow progression of coronary atherosclerosis in patients with coronary heart disease by lowering total-C and LDL-C.

Adult Dose for ALTOPREV:

Swallow whole. Individualize. ≥20yrs: 20–60mg once daily at bedtime; adjust at intervals of ≥4 weeks. Elderly (≥65yrs), renal insufficiency, diabetes: initially 20mg once daily at bedtime. Concomitant danazol, diltiazem, verapamil: max 20mg/day. Concomitant amiodarone: max 40mg/day. Severe renal insufficiency (CrCl<30mL/min): usual max 20mg/day.

Children's Dose for ALTOPREV:

<20yrs: not recommended.

Pharmacological Class:

HMG-CoA reductase inhibitor.

Contraindications:

Active liver disease. Unexplained persistent elevated serum transaminases. Pregnancy (Cat.X). Nursing mothers. Concomitant strong CYP3A4 inhibitors (eg, itraconazole, ketoconazole, posaconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone).

Warnings/Precautions:

Discontinue if myopathy, elevated CPK levels occur; suspend if a predisposition to development of renal failure secondary to rhabdomyolysis develops. Monitor liver function before starting therapy and repeat as clinically indicated. History of liver disease. Alcoholism. Homozygous familial hypercholesterolemia.

Interactions:

See Contraindications. Increased risk of myopathy with strong CYP3A4 inhibitors. May be potentiated by voriconazole, ranolazine; consider dose adjustment of lovastatin. Avoid gemfibrozil, cyclosporine, grapefruit juice >1 quart daily. Caution with, other fibrates, macrolides, niacin (≥1g/day), colchicine. Monitor oral anticoagulants. Inhibition of endogenous steroid production with spironolactone, ketoconazole, cimetidine.

Adverse Reactions:

Nausea, abdominal pain, insomnia, dyspepsia, headache, asthenia, myalgia, infection, accidental injury, elevated serum transaminases, myopathy, rhabdomyolysis with renal dysfunction; rare: immune-mediated necrotizing myopathy.

Note:

This product was formerly named Altocor.

How Supplied:

Tabs—30

ALTOPREV

  • 60mg tablets (Qty:7)
  • appx. price $119.00
GoodRx

Sign Up for Free e-newsletters