Allergic Disorders

Does Cetirizine Provide More Benefits Than Diphenhydramine for Acute Urticaria?

November 16, 2018

The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.

Does Prearrival Epinephrine Adversely Affect Pediatric Anaphylaxis Patients?

November 16, 2018

Despite many pediatric patients receiving higher than recommended doses of epinephrine for their weight, they did not present with epinephrine-related symptoms.

Oralair Approved for Younger Patients With Grass Pollen Allergy

By November 14, 2018

Oralair is indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollen specific IgE antibodies for any of the 5 grass species contained in this product.

Avocado Implicated in Several Food Protein-Induced Enterocolitis Syndrome Cases

By October 29, 2018

FPIES is a gastrointestinal food-associated hypersensitivity that often affects infants and toddlers and is marked by vomiting, diarrhea, fatigue, and pallor.

Expiration Dates Extended for Certain Lots of Generic Adrenaclick

By October 26, 2018

Epinephrine auto-injectors are indicated for the emergency treatment of allergic reactions (Type 1) including anaphylaxis.

BLA for Novel Peanut Allergy Treatment Submitted to FDA

By October 22, 2018

Viaskin Peanut, an epicutaneous immunotherapy (EPIT), delivers small amounts of peanut protein through a wearable patch to induce desensitization.

Dupilumab Studies Show Benefit in Chronic Rhinosinusitis With Nasal Polyps

By October 16, 2018

In both studies, at 24 weeks, patients treated with dupilumab plus corticosteroid nasal spray experienced a 51% and 57% improvement in nasal congestion/obstruction severity vs 15% and 19% improvement with nasal spray alone.

Omalizumab Improves Lung Function in Persistent Allergic Asthma

October 12, 2018

Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function after 16 weeks compared with those treated with placebo.

Xolair Prefilled Syringe Formulation Gets FDA Approval

By October 01, 2018

The PFS formulation eliminates the need to reconstitute the solution before administration.

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

By September 28, 2018

Both doses will be supplied in single-dose, prefilled syringes for manual injection.

Oral Allergy Treatments: Rx

September 26, 2018

A comparative dosing chart of prescription only oral medications for allergy treatment.

High-Risk Anticholinergics Prescribed to Six Percent of Elderly

September 25, 2018

The researchers found that a high-risk anticholinergic prescription was listed for 6.2% of visits of older adults between 2006 and 2015, representative of 14.6 million total visits nationally.

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

By September 13, 2018

According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.

Veta Smart Case, App for Epinephrine Auto-Injectors Now Available

By September 06, 2018

The Smart Case includes electronics and sensors to monitor the proximity, temperature, presence and removal, and expiration of auto-injectors.

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

By September 06, 2018

This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

By August 31, 2018

The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.

An Allergy to Red Meat May Be Tied to Heart Disease

August 31, 2018

The researchers found that 26% of patients had antibodies to α-Gal, indicating sensitivity to red meat. The sensitized patients had significantly higher levels of arterial plaque (30% higher) vs non-sensitized patients.

Novel Epinephrine Nasal Spray for Anaphylaxis Gets Fast Tracked by FDA

By August 31, 2018

The bioavailability of the novel epinephrine nasal spray also proved similar to that of intramuscular injection with EpiPen 0.3mg injection.

Many ED Visits for Antibiotic Adverse Drug Events in Children

August 31, 2018

Based on 6542 surveillance cases, the researchers estimated that 69,464 emergency department visits were made annually for antibiotic ADEs among children aged 19 years or younger from 2011 to 2015.

FDA Extends Expiration Date for Certain Lots of EpiPen

By August 21, 2018

This date modification beyond the approved 20-month shelf life was based an FDA review of product stability data submitted by Mylan.

First Generic Version of EpiPen Gets FDA Approval

By August 16, 2018

Unlike other generic approvals, epinephrine auto-injectors are considered "combination products" because they consist of both a drug and a device, making the approval process more challenging.

Xolair Designated Breakthrough Therapy for Food Allergies

By August 13, 2018

The FDA designation was supported by data from 7 studies evaluating the safety and efficacy of Xolair against various food allergens (eg, peanut, milk, egg, others).

Anaphylaxis Management

August 03, 2018

Anaphylaxis management for outpatients, inpatients, and patients at discharge.

Child-Targeted Gluten-Free Products No Healthier

July 23, 2018

Compared with child-targeted products without a GF claim, child-targeted GF products had lower levels of sodium, total fat, and saturated fat, and also had less protein, and a higher percentage of calories from sugar.

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

By July 11, 2018

In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.

Tick-Caused Meat Allergy on the Rise in the United States

July 09, 2018

Hives, skin rash, stomach problems, headaches, and trouble breathing are among the symptoms of the meat allergy. There is no treatment or cure.

Penicillin Allergy Linked to MRSA, <i>C. Difficile</i> Risk

June 29, 2018

Also among patients with penicillin allergy, the adjusted incidence rate ratios for antibiotic use were 4.15, 3.89, and 2.1 for macrolides, clindamycin, and fluoroquinolones, respectively. Increased use of β-lactam alternative antibiotics accounted for 55 and 35% of the increased risk of MRSA and C. difficile, respectively.

Allergic Conjunctivitis Treatments

June 26, 2018

A comparative dosing chart of prescription and over-the-counter (OTC) medications for allergic conjunctivitis treatment.

Most Adults Don't Use Their Epinephrine Auto-Injectors During Reactions

By June 21, 2018

Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

By June 20, 2018

Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.