FDA Approves Short Ragweed Pollen Allergen SL Tab

The FDA announced the approval of Ragwitek (Ambrosia artemisiifolia; Merck), the first sublingual allergen extract to treat short ragweed pollen induced allergic rhinitis, with or without conjunctivitis.

FDA Approves Timothy Grass Pollen SL Tab

Merck announced that the FDA has approved Grastek (Timothy grass pollen allergen extract) Tablet for Sublingual Use as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis.

First SL Allergy Immunotherapy Tablet Approved

Greer Laboratories announced that the FDA has approved Oralair sublingual allergy immunotherapy tablet for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis.

Xolair Gains Chronic Hives Indication

Genentech announced that the FDA has approved Xolair (omalizumab) injection for the treatment of chronic idiopathic urticaria (CIU).

Allergy Rates Vary for Children, Steady for Adults

Allergy prevalence is uniform across varying regions in the U.S, except in children ≤5 years old, according to an NIH study.

High-Dose Vitamin Beneficial in Chronic Urticaria

Adjuvant high-dose vitamin D3 is beneficial for patients with chronic urticaria.

'Talking' Medical Devices, Apps Continue to Evolve

"Talking" medical devices and apps, among other techy health-focused inventions, can help people manage everyday wellness routines, such as taking pills and checking blood sugar levels, as well as dire medical circumstances.

OTC Nasacort Allergy 24hr Nasal Spray Now Available

Sanofi and its consumer healthcare division Chattem announced that Nasacort (triamcinolone acetonide) Allergy 24hr Nasal Spray is now available over-the-counter (OTC).

Oral Immunotherapy Can Desensitize Children to Peanuts

Peanut oral immunotherapy (OIT) is efficacious for desensitization of children with peanut allergy.

Peanuts During Pregnancy Reduces Offspring Allergy Risk

Early allergen exposure may increase tolerance and lowers risk of childhood food allergy.

Study Supports AAP Allergy Prevention Recommendations

The delay of solid foods until ≥17 weeks of age and continued breastfeeding when cow's milk protein is introduced to infants' diets correlate with a reduced likelihood of food allergies.

Obama Signs Bill to Encourage Schools to Stock Epinephrine

President Obama signed a new law meant to increase the availability of life-saving epinephrine in U.S. schools on Wednesday.

Sublingual Immunotherapy Tablet Reduces Allergy Symptoms in Trial

Merck announced data for its investigational Timothy grass sublingual allergy immunotherapy tablet (MK-7243) to treat the underlying cause of allergic rhinitis.

Non-Celiac Wheat Sensitivity May Be an Allergy

Non-celiac wheat sensitivity (NCWS) may be a non-immunoglobulin E-mediated food allergy.

ACAAI: Moms' Immunotherapy May Cut Offspring Allergy Risk

Mothers' receipt of immunotherapy during pregnancy may reduce the risk of any type of allergy in offspring.

Chronic Condition Prevention Urged for Better Life Quality

Multiple chronic conditions are associated with worse health in terms of activities of daily living and health-related quality of life in older adults.

Flu Vaccine Recommendations Updated for Egg-Allergic

Patients with egg allergy face no increased danger from receiving injectable inactivated influenza vaccine as a single dose.

Researchers Estimate Costs of Childhood Food Allergies

Childhood food allergies result in significant direct medical costs for the U.S. health care system and even larger total costs for families of food-allergic children.

Early-Life Probiotics Reduce Allergies, Not Asthma

Probiotic exposure in early life may reduce total immunoglobulin E level (IgE) and protect against atopic sensitization, but does not seem to protect against asthma/wheezing.

AidaPak Recalls Incorrectly Labeled Drug Products

AidaPak is initiating a voluntary recall for strip packs at the hospital/user level after learning of possible incorrect labeling.

Food Allergy Treatment Loses Efficacy With Time

Children treated successfully for milk allergies with oral immunotherapy lose tolerance after several years.

MRI Screening Identifies Undiagnosed Spinal Infections

About a fifth of patients who have received a spinal injection of fungus-contaminated methylprednisolone but have not sought medical care are likely to be infected.

Adrenaclick Auto-Injector Available Again for Anaphylaxis

Amedra announced the relaunch of Adrenaclick (epinephrine) auto-injector for the emergency treatment of anaphylaxis.

Joint Supplement Contains Undeclared Allergens

Atriphen has been recalled due to the possibility of causing a severe allergic reaction from two undeclared allergens.

Immunotherapy Tablet Under Review for Allergies

The FDA has accepted for review the Biologics License Application for ragweed pollen sublingual allergy immunotherapy tablet.

Parental Saliva on Infant's Pacifier Protects From Allergies

Parental sucking of their infant's pacifier is associated with a reduced risk of allergy development.

Last 14 Years Saw Increase in Allergies Among U.S. Children

For U.S. children aged younger than 18 years, the prevalence of allergies increased from 1997-2011, with age, race/ethnicity, and income all affecting the prevalence.

Recall: Undeclared Milk Components in ebA Multivitamin Supplement

Saratoga Therapeutics recalled 900 bottles of ebA Multivitamin Supplement because they may contain undeclared milk components such as milk protein(s) and lactose.

MyAllergyTest Approved; Allows At-Home Allergy Testing

MyAllergyTest, a lab-based quantitative IgE and allergy diagnostic, is the first FDA-approved at-home test that allows allergy patients to test themselves against 10 key allergens.

Delayed Allergy Reactions Seen With Pediatric Meat Consumption

Immunoglobulin E antibody specific for galactose-α1,3-galactose, which is associated with delayed anaphylaxis and urticaria that occurs several hours after eating beef, pork, or lamb, has been identified in children reporting idiopathic anaphylaxis or urticaria.

Karbinal ER Approved to Treat Allergic Rhinitis

The FDA has approved the New Drug Application for Tris Pharma's Karbinal Extended-Release Oral Suspension. Karbinal is used to treat seasonal and perennial allergic rhinitis in children 2 years of age and older.

Alert: Pallimed Solutions Recalls All Sterile Compounds

After visible particulates were found in product vials, Pallimed Solutions is voluntarily recalling all sterile compounds dispensed since January 1, 2013. Particulate matter can potentially damage or obstruct blood vessels.

Merck's BLA for Allergy Immunotherapy Tablet Accepted for Review

Merck's Biologics License Application was accepted for its investigational Timothy grass pollen allergy immunotherapy tablet (AIT). In March, the company submitted a BLA for its investigational ragweed pollen AIT.

AAD: Complications of Tattoos and Tattoo Ink Discussed

Complications linked to tattoos and tattoo inks include allergic reactions, serious infections, and reactions that can be mistaken for skin cancer.

Phase 3 Study Results Announced for Omalizumab in CIU

Genentech and Novartis announced the results from a Phase 3 study, ASTERIA II, which showed that omalizumab, met its primary endpoint in patients with moderate to severe chronic idiopathic urticaria (CIU), who remained symptomatic despite treatment with approved H1 antihistamine doses.

Acupuncture May Help Treat Seasonal Allergies

Acupuncture produces statistically significant improvements in disease-specific quality of life and reduces antihistamine use in patients with seasonal allergic rhinitis (SAR), although further study is required to determine whether these results are clinically significant.

Auvi-Q Auto-Injector Now Available

Sanofi announced that Auvi-Q (epinephrine injection) is now available.

Almost Half of Children With Food Allergy Report Being Bullied

For children with food allergy, bullying is common, and correlates with decreased quality of life and increased distress for children and their parents.

ACAAI: Baked Eggs Tolerated by Some Egg-Allergic Children

Just over half of children with hen egg allergies can tolerate baked eggs in an oral food challenge (OFC); and more than a quarter of children over the age of 10 with food allergies develop tolerance.

AACR: Hay Fever, Asthma Tied to Lower Colorectal Cancer Death

People with both hay fever and asthma have a modestly reduced risk of dying from colorectal cancer.

Study Examines Prevalence of Local Allergic Rhinitis

Local allergic rhinitis (LAR) is prevalent among patients with rhinitis, affecting about one in four, and is often associated with childhood onset and persistent, severe conjunctivitis and/or asthma.

Perceived Stress Linked to Asthma, Atopic Disorders

Perceived stress correlates with an increased risk of adult-onset asthma, allergic rhinitis, and atopic dermatitis as well as asthma medication use.

Parent-Reported Child Food Allergies Often Unsubstantiated

Nearly one-third of parent-reported food allergies are not formally diagnosed by a physician

Advertising Changes After Drug Switch to Over-the-Counter

When a drug switches from prescription-only to over-the-counter (OTC) there is a shift in the direct-to-consumer advertising (DTCA), with less presentation of potential harms and frequent omission of identification by generic names.

Ecallantide Efficacious for Hereditary Angioedema Attacks

Patients with unpredictable and recurring attacks of acute hereditary angioedema (HAE) may be effectively treated with ecallantide, with relapse occurring in a small proportion of patients and little evidence of rebound.

Mylan Offers Free EpiPen Auto-Injectors to Schools

Mylan Specialty announced the EpiPen4Schools program, which offers four free EpiPen (epinephrine 0.3mg; DEY Pharma) or EpiPen Jr (epinephrine 0.15mg; DEY Pharma) Auto-Injectors upon qualification.

Auvi-Q Auto-Injector Approved for Anaphylaxis

Sanofi announced that the FDA has approved Auvi-Q (epinephrine injection) for the emergency treatment of life-threatening allergic reactions in people who are at risk for or have a history of anaphylaxis.

High IgE Levels Inversely Associated With Risk of Glioma

There appears to be an inverse relationship between elevated allergy biomarker levels (immunoglobulin E [IgE]) and the risk of developing glioma, which is detectable many years before tumor diagnosis.

Cases of Delayed Anaphylaxis to Red Meat Described

Individuals who have been bitten by the lone star tick may develop immunoglobulin E (IgE) to the carbohydrate galactose-α-1,3-galactose (alpha-gal), which puts them at risk for delayed anaphylaxis after consumption of meat containing alpha-gal on glycoproteins or glycolipids.

Zetonna Now Available for Allergic Rhinitis

Sunovion announced the nationwide availability of Zetonna (ciclesonide) Nasal Aerosol, 74mcg once-daily, for the treatment of allergic rhinitis (AR), also known as hay fever or nasal allergies.

Stability of Fragrance Patch Test Preparations Examined

Concentrations of several fragrance allergens applied to test chambers well in advance of patient testing may be reduced by >20% within hours when stored at room temperature.

Oral Immunotherapy Promising for Children With Egg Allergy

Oral immunotherapy represents a promising therapeutic intervention for children with egg allergy.

Handling of Confounding in Diet and Asthma, Allergy Studies Poor

Studies investigating the effect of diet on the development of childhood asthma and allergies generally have substantial shortcomings with regard to how they handle confounding and effect modification.

Prenatal Exposure to Butylbenzyl Phthalate Linked to Eczema

Prenatal exposure to butylbenzyl phthalate (BBzP), as assessed by increased concentrations of monobenzyl phthalate (MBzP) in the urine, is associated with an increased risk of early-onset eczema in offspring.

Accidental Exposure Causes Most Reactions in Allergic Infants

For infants with documented or likely allergies to milk or eggs, most allergic reactions result from accidental exposures.

A Shift in Pediatric Drug Utilization Seen 2002 to 2010

From 2002-2010 there was a 7% decrease in outpatient pediatric prescription medication utilization, due in part to a decrease in antibiotics and allergy medication prescriptions.

Child Food Allergy Prevalence Linked to Urban/Rural Status

The prevalence of childhood food allergy is associated with urban/rural status, even after adjusting for confounding variables.

Allergens Higher in Ragweed Pollen Near Busy Roads

Roadside ragweed pollen exposed to pollution from heavy automobile traffic is more allergenic than pollen from similar plants found near less-traveled roads or in vegetated areas.

Dymista Approved for Allergic Rhinitis

Meda announced that the FDA has approved Dymista (azelastine HCl and fluticasone propionate) nasal spray for the treatment of seasonal allergic rhinitis.

Food Allergy Risk Up for Children Born in the Fall

Children born in the fall have an increased risk of food allergy, with a significantly increased risk seen only for Caucasians and those with eczema.

Novel Lipocalin Dog Allergen Cross-Reacts With Cat, Horse

A novel lipocalin dog allergen has been identified in nearly 40% of dog-sensitized individuals, which cross-reacts with lipocalins from cat and horse.

RECALL: Epinephrine Injection 1:1000 Ampules Recall

American Regent is conducting a nationwide voluntary recall of Epinephrine Injection, 1:1000, 1mL ampules (NDC #0517-1071-25; Lot #1395; Exp Date: July 2012).

Majority of Children Affected by Allergy-Related Diseases

Eczema, asthma, and rhinitis occur in 58 percent of children; 7.5 percent have comorbidities

QNASL Approved for Seasonal and Perennial Allergic Rhinitis

Teva announced that the FDA has approved QNASL (beclomethasone dipropionate) Nasal Aerosol, a non-aqueous, "dry" nasal aerosol corticosteroid for the treatment of seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.

Fast-Updosed Subcutaneous Immunotherapy Effective

An immunologically-enhanced subcutaneous immunotherapy (SCIT) formulation, with an optimized ratio of allergen to adjuvant, induces a significant immunologic response with acceptable safety when injected every three to four days compared with standard weekly injections.

Neonatal Size Associated With Asthma Development

Larger neonates born at term to mothers with a history of asthma are more likely to develop asthma by age 7, but are not more likely to have allergic sensitization or atopic dermatitis.

AAAAI: Prevalence of Asthma, Hay Fever Lower Among Amish

The prevalence of asthma, hay fever, and allergic sensitization is significantly lower among the Amish population than among Swiss children.

AAAAI: Asthma Patients More Tolerant of Food Challenges

Asthma patients with a history of food allergy are less likely than similar individuals without asthma to fail an oral food challenge.

Phase 3 Study of QNASL for Seasonal and Perennial Allergic Rhinitis

Teva announced findings from four Phase 3 clinical studies that examined the efficacy and safety profile as well as impact on quality of life (QoL) of QNASL (beclomethasone dipropionate [BDP]) Nasal Aerosol, a non-aqueous, "dry" nasal aerosol corticosteroid in development for the treatment of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR).

Phase 3 Study of Allergy Immunotherapy Tablet (AIT) for Ragweed Allergy

Merck announced the results from its Phase 3 study of its investigational Ambrosia artemisiifolia (ragweed) allergy immunotherapy tablet (AIT) for ragweed pollen allergy.

Allergy-Related Diseases Affect Majority of Children

Eczema, asthma, and rhinitis affect >50% of children up to age 12.

Abortive Acupuncture Reduces Allergen-Induced Itch

Acupuncture and cetirizine both reduce type I hypersensitivity itch better than placebo or no intervention.

Prenatal Stress May Affect Infant Immune System

A woman's prenatal exposure to high stress and dust mite allergens may interact to affect the immune system of her offspring.

SAFETY ALERT: Nostrilla Nasal Decongestant Recalled

The FDA has notified healthcare professionals and consumers that Insight Pharmaceuticals has recalled one lot of Nostrilla Nasal Decongestant (Oxymetazoline HCl nasal spray) because it may contain the bacteria Burkholderia cepacia.

EpiPen and EpiPen Jr Single Packages Discontinued; To Be Supplied in 2-Paks

Dey Pharma announced that it will be supplying only EpiPen 2-Pak and EpiPen Jr 2-Pak (epinephrine auto-injector) and transitioning away from the EpiPen and EpiPen Jr single packages.

NDA Accepted for BDP Nasal HFA for Allergic Rhinitis

Teva announced that the FDA has accepted its New Drug Application (NDA) for BDP Nasal HFA (beclomethasone dipropionate hydrofluoroalkane) for the treatment of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) after its submission in May 2011.

RECALL: American Regent Recalls Calcium Gluconate Injection 10%

American Regent is conducting a voluntary nationwide recall of one lot of calcium gluconate injection 10% because some of the vials may contain silicone particles.

Phase 3 Results for Dymista for Allergic Rhinitis

Meda announced new results from its Phase 3 study of Dymista (azelastine HCl and fluticasone propionate; Meda) nasal spray for the treatment of allergic rhinitis.

NDA Accepted for Dymista for Allergic Rhinitis

The FDA has accepted for filing the NDA for Dymista (azelastine HCl and fluticasone propionate; Meda) nasal spray for the treatment of allergic rhinitis.

Arbinoxa Tablets and Oral Solution Available for Allergies

Hawthorn Pharmaceuticals announced that Arbinoxa (carbinoxamine) tablets and oral solution are available for the treatment of allergic (seasonal and perennial) and vasomotor rhinitis, conjunctivitis, urticaria, angioedema, and reactions to blood.

Phase 3 Study of Dymista for Seasonal Allergic Rhinitis

Meda announced positive results from its Phase 3 trial of Dymista (azelastine HCl and fluticasone propionate) nasal spray in patients with seasonal allergic rhinitis

American Regent Recalls Sodium Chloride and Dexamethasone Injections

American Regent announced a voluntary nationwide recall of concentrated sodium chloride injection, bacteriostatic sodium chloride injection, and dexamethasone sodium phosphate injection.

Phase 3b study of RHUCIN for the treatment of acute hereditary angioedema

Santarus and Pharming announced initiation of their Phase 3b study of RHUCIN (recombinant human C1 inhibitor) for the treatment of acute attacks of angioedema in patients with hereditary angioedema.

FDA reminder of safe non-sterile alcohol prep pad use

The FDA is reminding healthcare professionals about the safe use of non-sterile alcohol prep pads to clean and disinfect the surface of the skin.

Allegra and Allegra-D Approved for Over-The-Counter Use

The FDA has approved sanofi-aventis' Allegra and Children's Allegra (fexofenadine) and Allegra-D (fexofenadine and pseudoephedrine) product lines to be marketed over-the-counter.

New guidelines for food allergy

The National Institute of Allergy and Infectious Diseases (NIAID) Issues issued a new clinical practice guideline to assist healthcare professionals in the diagnosis and management of food allergy.

Phase 3 study of Firazyr for the treatment of hereditary angioedema (HAE)

Shire announced topline results from FAST-3, the largest of its Phase 3 trials studying the use of Firazyr (icatibant) for treatment of acute attacks of hereditary angioedema (HAE).

McNeil Consumer Healthcare product supply update

McNeil Consumer Healthcare announced that it does not anticipate having sources of supply for most of the products that were produced at its Fort Washington, Pennsylvania manufacturing facility before the end of 2010.

Vicks Sinex VapoSpray 4-Hour Decongestant Nasal Spray recalled

Procter & Gamble announced a voluntary nationwide recall of Vicks Sinex VapoSpray 4-Hour Decongestant Nasal Spray (oxymetazoline HCl).

McNeil recalls Benadryl Allergy Ultratab and Extra Strength Tylenol Rapid Release Gels

McNeil Consumer Healthcare has expanded its January 15, 2010 recall to include four lots of Benadryl Allergy (diphenhydramine) Ultratab Tablets and one lot of Extra Strength Tylenol (acetaminophen) Rapid Release Gels.

GammaGard Liquid recalled

The FDA and Baxter BioScience have notified healthcare professionals of a voluntary market withdrawal being conducted as a precautionary measure due to an increased number of adverse event reports of allergic reactions associated with two lots of GammaGard Liquid (immune globulin intravenous [human]).

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