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ALDACTONE
Edema
Hypertension
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Drug Name:

ALDACTONE Rx

Generic Name and Formulations:
Spironolactone 25mg, 50mg+, 100mg+; tabs; +scored.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for ALDACTONE:

Edema.

Adult Dose for ALDACTONE:

Initially 25–200mg daily. Usual starting dosage: 100mg/day in single or divided doses. Maintain for 5 days, then retitrate.

Children's Dose for ALDACTONE:

Initially 3.3mg/kg per day in single or divided doses.

Pharmacological Class:

K+-sparing.

Contraindications:

Hyperkalemia. Renal impairment.

Warnings/Precautions:

Hepatic cirrhosis. Hyponatremia. Surgery. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Potentiates ganglionic blockers, alcohol, barbiturates, narcotics, skeletal muscle relaxants. Digitalis toxicity.

Adverse Reactions:

Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis.

How Supplied:

Tabs 25mg—100, 500, 2500; 50mg, 100mg—100

Indications for ALDACTONE:

Adjunct in hypertension.

Adult Dose for ALDACTONE:

Initially 50–100mg/day in single or divided doses. Titrate at 2 week intervals.

Children's Dose for ALDACTONE:

Not recommended.

Pharmacological Class:

Diuretic (K+ sparing).

Contraindications:

Hyperkalemia. Renal impairment. Anuria.

Warnings/Precautions:

Hepatic cirrhosis. Hyponatremia. Surgery. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Potentiates ganglionic blockers, alcohol, barbiturates, narcotics, skeletal muscle relaxants. Digitalis toxicity.

Adverse Reactions:

Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis.

How Supplied:

Tabs 25mg—100, 500, 2500; 50mg, 100mg—100