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ALDACTAZIDE
Edema
Hypertension
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Drug Name:

ALDACTAZIDE Rx

Generic Name and Formulations:
Spironolactone, hydrochlorothiazide; 25mg/25mg, 50mg/50mg+; tabs; +scored.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts

Therapeutic Use:

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Indications for ALDACTAZIDE:

Edema.

Adult Dose for ALDACTAZIDE:

Not for initial therapy. Usual maintenance: 4 tabs daily in single or divided doses.

Children's Dose for ALDACTAZIDE:

Not for initial therapy. Usual maintenance: 1.65–3.3mg spironolactone per kg daily.

Pharmacological Class:

K+-sparing + thiazide.

Contraindications:

Hyperkalemia. Anuria. Renal impairment. Sulfonamide allergy. Severe hepatic impairment.

Warnings/Precautions:

Hepatic cirrhosis. Hyponatremia. Surgery. Gout. Diabetes. SLE. Postsympathectomy. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants. May need to adjust insulin or oral hypoglycemic dosage. Antagonized by NSAIDs. Digitalis toxicity. May interfere with parathyroid tests.

Adverse Reactions:

Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis. Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

How Supplied:

Tabs—100, 2500

Indications for ALDACTAZIDE:

Hypertension.

Adult Dose for ALDACTAZIDE:

Usual maintenance: 50–100mg each of spironolactone and HCTZ daily in single or divided doses.

Children's Dose for ALDACTAZIDE:

Not recommended.

Pharmacological Class:

Diuretic combination.

Contraindications:

Hyperkalemia. Anuria. Renal impairment. Sulfonamide allergy. Severe hepatic impairment.

Warnings/Precautions:

Hepatic cirrhosis. Hyponatremia. Surgery. Gout. Diabetes. SLE. Postsympathectomy. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants. May need to adjust insulin or oral hypoglycemic dosage. Antagonized by NSAIDs. Digitalis toxicity. May interfere with parathyroid tests.

Adverse Reactions:

Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis. Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

How Supplied:

Tabs—100, 2500