Empagliflozin Cuts CVD Risk in Patients With Type 2 Diabetes, PAD

Empagliflozin reduced the risk of cardiovascular death by 43%
Empagliflozin reduced the risk of cardiovascular death by 43%

Empagliflozin (Jardiance; Boehringer Ingelheim and Lilly) lowered the risk of cardiovascular death versus placebo when added to standard of care in adults with both type 2 diabetes and peripheral artery disease, according to data presented at the American Heart Association (AHA) Scientific Sessions 2017

The findings are from a post-hoc analysis of the EMPA-REG OUTCOME trial (n>7,000). At study initiation, 21% of the total study subjects had existing peripheral artery disease. Data from this patient group showed that empagliflozin cut the risk of cardiovascular death by 43% compared with placebo. All-cause mortality was lowered by 38% and hospitalization for heart failure by 44%. 

Moreover, the risk for the composite endpoint (cardiovascular death, non-fatal heart attack or non-fatal stroke) was reduced by 16% and nephropathy was cut by 46%. The cardiovascular and renal effects seen with this patient group were consistent with previously observed data of the overall EMPA-REG OUTCOME trial population. 

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Lower-limb amputations occurred in 5.5% of peripheral artery disease patients in the empagliflozin-treated group compared to 6.3% in the placebo group.

Jardiance, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, is currently indicated along with diet and exercise to lower blood sugar in adults with type 2 diabetes, and to reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease.  

For more information visit Jardiance.com.