AES 2017

Vigabatrin Evaluated for Focal Seizures in Tuberous Sclerosis

By December 05, 2017

Families often preferred to remain on treatment despite the risk of vision loss.

Perampanel as Add-On Tx May Benefit in Severely Refractory Focal Epilepsy

By December 05, 2017

The results suggest that a change in the way perampanel is initiated may be warranted.

Non-Drug Therapies, Ketogenic Diet May Offer Seizure Relief for Children

December 05, 2017

Researchers examined seizure outcome at 6 months following slow initiation of KD in 40 children. The diet was initiated at a very low ratio (0.6 to 1:1) and was increased gradually depending on the tolerability and desired seizure control.

Does Maternal Antibiotic Use Up the Risk for Neonatal Seizures?

By December 04, 2017

Researchers assessed the relationship between maternal antibiotic use and neonatal seizures in infants (>32 weeks gestation).

Eslicarbazepine Acetate Examined in Children With Partial-Onset Seizures

By December 04, 2017

ESL is not currently FDA-approved for use in pediatric patients.

Safety, Efficacy of AEDs Assessed in Elderly Epileptic Patients

By December 04, 2017

When compared to lamotrigine, levetiracetam was found to increase seizure-freedom, however, it was also associated with an increased risk of side effects.

Low-Dose Fenfluramine Cuts Convulsive Seizure Frequency in Dravet Syndrome

By December 04, 2017

Odds of achieving a clinically meaningful (≥50%) or substantial (≥75%) reduction in convulsive seizure frequency were 29 and 50 times higher, respectively, among patients treated with ZX008 than in patients treated with placebo.

Pregabalin Evaluated in Pediatric Patients With Partial Onset Seizures

By December 04, 2017

For all POS and for most POS subtypes, pregabalin resulted in a numerically greater percentage of subjects who exhibited categorical decreases in seizure frequency vs placebo.

Antiepileptic Drugs and Suicide-Related Behavior: What's the Link?

By December 03, 2017

Trends of suicide related behavior were compared before and after initiation of AED therapy among AED users with and without epilepsy to individuals without AED use.

Clobazam Combo Tx Beneficial in Lennox−Gastaut Syndrome

By December 03, 2017

At baseline, the patients included in the study were an average (SD) age of 12.4 (9.0) years old with an average (SD) 86.6 (161.5) drop seizures/week.

Continuous Infusion Linked to Worse Outcomes in Pediatric RSE

December 03, 2017

Researchers compared outcomes between patients treated with continuous infusion or repeated doses of nonbenzodiazepine anti-seizure medication.

Lacosamide Analyzed Among Pediatric Population With Drug-Resistant Epilepsy

By December 03, 2017

Children were classified as those under 21 years old.

BMD Loss Prevention Should Be Considered in Patients With Epilepsy

December 03, 2017

Treatment algorithms are needed for patients with epilepsy who present with evidence of bone loss.

Long-Term Trial Assesses Cannabidiol Safety, Efficacy in Patients with LGS

By December 03, 2017

Cannabidiol in oral solution was evaluated for safety, drop-seizure frequency, total-seizure frequency, and S/GIC change in patients with Lennox-Gastaut Syndrome.

Reperfusion Tx May Up the Risk of Seizure in Stroke Patients

December 03, 2017

Patients undergoing treatment for ischemic stroke are at greater risk for seizure development.

Does PAP Therapy Improve Seizure Control in Epilepsy Patients With OSA?

December 03, 2017

Treatment with positive airway pressure may help retain or improve seizure control in patients with epilepsy and obstructive sleep apnea.

Review Examines Frequency of Drug-Induced Myoclonus

By December 02, 2017

Gabapentin (GBP)- and pregabalin (PGB)-induced myoclonus is commonly seen but rarely documented or discussed.

What Impact Does Epilepsy Surgery Have on Cognition?

December 02, 2017

Preoperative cognitive function is a central component of predicting cognitive outcomes after resective epilepsy surgery.

Vitamin B6 May Help Treat Levetiracetam-Induced Behavioral Effects

By December 02, 2017

Behavioral side effects are a common cause of levetiracetam discontinuation.

Effectiveness of Infantile Spasm Treatments Compared

By December 02, 2017

Results found that infants with an unknown epilepsy etiology, a normal MRI, an EEG displaying hypsarrhythmia, or those already receiving an AED were more likely to be administered ACTH.

Eslicarbazepine Effective After Transitioning From Carbamazepine, Oxcarbazepine

By December 02, 2017

The study had a 70.0% responder rate and there was a 30.9% seizure freedom rate after 12 months of ESL treatment for patients transitioning from carbamazepine due to lack of efficacy.

Relationship Between Seizure Onset and Year of Menarche Examined

December 02, 2017

Researchers suggest the combined effects of adrenarche and menarche may play a role in the relationship

Length of Refractory Status Epilepticus May ID Future Neurologic Issues

December 02, 2017

Approximately one-third of pediatric patients with refractory convulsive status epilepticus develop neurologic deficits.

RNS Tablet Allows Clinicians to Review ECoG Data, Personalize Therapy

By December 01, 2017

The Tablet's display includes more customizable info on electrocorticographic trends and there are now less steps needed to adjust settings.