Select therapeutic use:
Indications for ACTHREL:
For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.
Adults and Children:
Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.
Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.
Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.
Corticotropin-releasing hormone (CRH) analogue.
Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.