ACIPHEX

Generic Name for ACIPHEX Rabeprazole sodium 20mg; delayed-release, e-c tabs. Legal Classification: Rx Pharmacological Class for ACIPHEX Proton pump inhibitor. Manufacturer of ACIPHEX PriCara

Indications for ACIPHEX

Triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment of erosive or ulcerative gastroesophageal reflux disease (GERD) or duodenal ulcers. Treatment of symptomatic GERD in patients ≥12 years of age. Maintenance of healing and reduction in relapse rates of heartburn symptoms in erosive or ulcerative GERD. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).

Adult dose for ACIPHEX

Swallow whole. ≥18 years: Triple therapy: rabeprazole 20mg + amoxicillin 1g + clarithromycin 500mg, all twice daily (w. AM and PM meals) for 7 days. GERD healing: 20mg once daily for 4–8 weeks; may repeat for 8 more weeks. GERD symptoms: 20mg once daily for 4 weeks; may repeat for 4 more weeks. GERD maintenance: 20mg once daily. Duodenal ulcer healing: 20mg once daily after breakfast for up to 4 weeks. Hypersecretory conditions: initially 60mg once daily; titrate; doses up to 100mg once daily or 60mg twice daily have been used.

Children's dosing for ACIPHEX

<12 years: not recommended. ≥12 years: Short-term treatment of GERD: 20mg once daily for up to 8 weeks.

Warnings/Precautions for ACIPHEX

Severe hepatic impairment. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions for ACIPHEX

May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, digoxin). May give antacids concomitantly. May antagonize atazanavir (not recommended). Monitor warfarin, cyclosporine.

Adverse Reactions for ACIPHEX

Headache, pain, pharyngitis, flatulence, infection, constipation. Children: also nausea.

Extra Text:

See Amoxil entry for more information on amoxicillin. See Biaxin entry for more information on clarithromycin.

How is ACIPHEX supplied?

Tabs—30, 90