ACEON Rx

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ACEON

CHF and arrhythmias
Hypertension
Only 4 drugs may be compared at once

Generic Name and Formulations:

Perindopril erbumine 2mg, 4mg, 8mg; scored tabs.

Company:

Symplmed

Select therapeutic use:

Indications for ACEON:

To reduce risk of cardiovascular mortality or nonfatal MI in patients with stable coronary artery disease.

Adult:

Initially 4mg once daily for 2 weeks, then increase as tolerated; maintenance: max 8mg once daily. Renal impairment: CrCl <30mL/min: not recommended; CrCl >30mL/min: initially 2mg/day: max 8mg/day.

Children:

Not established.

Elderly:

>70yrs: initially 2mg once daily for 1st week, then 4mg once daily for 2nd week; maintenance: 8mg once daily, if tolerated.

Contraindications:

History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:

Fetal toxicity may develop: discontinue if pregnancy is detected. Salt/volume depletion. Dialysis. Severe CHF. Renal artery or aortic stenosis. Monitor BP, electrolytes, and renal function periodically. Diabetes. Monitor for neutropenia in renal or collagen vascular disease (eg, SLE). Hepatic impairment. Surgery. Discontinue if laryngeal edema, angioedema (have SC epinephrine available), marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers.

Interactions:

See Contraindications. Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes, others (eg, cyclosporine, indomethacin, heparin). May increase lithium levels. Caution with gentamicin, digoxin. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. Nitritoid reactions with concomitant injectable gold (eg, sodium aurothiomalate); rare.

Pharmacological Class:

ACE inhibitor.

Adverse Reactions:

Headache, cough, dizziness, back pain, drug intolerance, hypotension, fever; hyperkalemia.

How Supplied:

Tabs—100

ACEON 4mg tablets (Qty:30)

appx. price $84.00

Indications for ACEON:

Hypertension.

Adult:

If not on diuretic: initially 4mg once daily. Titrate; max 16mg/day. Usual maintenance 4–8mg as a single daily dose or in two divided doses. If on diuretic: consider reducing diuretic dose prior to starting therapy. Renal impairment: CrCl <30mL/min: not recommended; CrCl >30mL/min: initially 2mg/day: max 8mg/day.

Children:

Not established.

Elderly:

>65yrs: usual max 8mg/day.

Contraindications:

History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:

Fetal toxicity may develop: discontinue if pregnancy is detected. Salt/volume depletion. Dialysis. Severe CHF. Renal artery or aortic stenosis. Monitor BP, electrolytes, and renal function periodically. Diabetes. Monitor for neutropenia in renal or collagen vascular disease (eg, SLE). Hepatic impairment. Surgery. Discontinue if laryngeal edema, angioedema (have SC epinephrine available), marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers.

Interactions:

See Contraindications. Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes, others (eg, cyclosporine, indomethacin, heparin). May increase lithium levels. Caution with gentamicin, digoxin. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. Nitritoid reactions with concomitant injectable gold (eg, sodium aurothiomalate); rare.

Pharmacological Class:

ACE inhibitor.

Adverse Reactions:

Headache, cough, dizziness, back pain, drug intolerance, hypotension, fever; hyperkalemia.

How Supplied:

Tabs—100

ACEON 4mg tablets (Qty:30)

appx. price $84.00