Register for your FREE account now and join the thousands of healthcare professionals who have depended on us for over 26 years for accurate, concise, and timely drug information.

Email*

Password*

Keep me logged in Forgot your password?

Email*

ABSTRAL

Compare to Similar Drugs | Add to Clipboard | View Clipboard | Print | Email

Close [X]

Compare ABSTRAL to:

ABSTRAL (fentanyl) transmucosal immediate-release tablets by ProStrakan

Generic Name for ABSTRAL

Fentanyl 100mcg, 200mcg, 300mcg, 400mcg, 600mcg, 800mcg; sublingual tablets.

Legal Classification:

CII

Pharmacological Class for ABSTRAL

Opioid.

Manufacturer of ABSTRAL

ProStrakan, Inc.

Indications for ABSTRAL

Breakthrough pain, in opioid-tolerant patients already receiving and who are tolerant to continuous opioid therapy for underlying persistent cancer pain. Opioid-tolerant patients are those taking: Oral morphine ≥60mg/day, oxycodone ≥30mg/day, hydromorphone ≥8mg/day, oxymorphone ≥25mg/day, or equianalgesic dose of another opioid for ≥1 week; or transdermal fentanyl ≥25mcg/hr.

Adult dose for ABSTRAL

≥18yrs: Do not chew, suck, swallow tablets. Allow tablets to dissolve in sublingual cavity. Do not eat or drink until tablet completely dissolves. Individualize. Initially one 100mcg dose; if adequate analgesia is obtained within 30min, continue to treat subsequent episodes with this dose. If inadequate, give 2^nd dose (after 30min). For future episodes, if analgesia is not obtained with 100mcg dose, titrate in increments of 100mcg up to 400mcg as needed; if 400mcg dose is inadequate, titrate to 600mcg dose, then 800mcg dose if needed. May use 100mcg or 200mcg tablets for any single dose; max 4 tabs at one time. Max 2 doses/episode, up to 4 episodes/day. Wait at least 2hrs before treating another episode. Maintenance: use only one tablet of appropriate strength. Do not convert from other fentanyl products on a mcg per mcg basis or interchange with other fentanyl products. Rescue medication may be used.

Children's dosing for ABSTRAL

<18yrs: not recommended.

Contraindications for ABSTRAL

Not for opioid non-tolerant patients. Acute or post-op pain (including headache/migraine, dental pain, or ER).

Warnings/Precautions for ABSTRAL

Respiratory disorders or depression. Head injury. Increased intracranial pressure. Bradyarrhythmias. Impaired pulmonary, cardio, renal, or hepatic function. Elderly. Debilitated. Pregnancy (Cat. C). Labor & delivery, nursing mothers: not recommended.

Interactions for ABSTRAL

Not recommended within 14 days of MAOIs. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, skeletal muscle relaxants, antihistamines, hypnotics). Potentiated by CYP3A4 inhibitors (eg, macrolides, azole antifungals, aprepitant, protease inhibitors, nefazodone, verapamil, diltiazem). Antagonized by CYP3A4 inducers (eg, barbiturates, efavirenz, modafinil, nevirapine, anticonvulsants, pioglitazone, troglitazone, rifabutin, rifampin, St John’s wort).

Adverse Reactions for ABSTRAL

Nausea, somnolence, headache, constipation; respiratory/circulatory depression.

Notes for ABSTRAL

Available by restricted distribution program. Call (888) 227-8725 to enroll. Properly handle and dispose; may be fatal to children.

How is ABSTRAL supplied?

Sublingual tabs—32

Related Disease:

Pain, general~narcotics

Low Back Pain Improves Soon After Treatment, but Still Lingers

May 15, 2012

For patients with acute or persistent low back pain, pain and disability improve in the first six weeks of treatment, but low-to-moderate pain and disability tend to persist at one year.

Nonmedical Prescription Pain Medication Use Peaks at Age 16

May 10, 2012

Use of prescription pain relievers to get high or for other nonmedical purposes (extramedical use) peaks around age 16 years.

PAS: Maternal Opioid Use, Neonatal Withdrawal Rising

May 01, 2012

From 2000-2009, there was a significant increase in the incidence of maternal opioid use and in the diagnosis of neonatal abstinence syndrome (NAS).

Hyperalgesia Similar With Drug Therapies for Heroin Addiction

April 26, 2012

Heroin-addicted patients treated with methadone or buprenorphine have a heightened sensitivity to pain, and the hyperalgesia does not change over the course of treatment.

Patients With Acute Low Back Pain Have Poor Prognosis

April 24, 2012

Few patients with acute low back pain (LBP), with or without sciatica, declare sick leave; however, approximately half have one or more recurrences and a considerable proportion experience chronic pain six months or longer after the initial episode.