Treatment with extended release naltrexone/bupropion (NB) for weight loss significantly improved and normalized serum ALT levels in obese and overweight individuals at high risk for non-alcoholic fatty liver disease (NAFLD) with elevated liver enzymes, reported Allison Winokur, PhD, from Takeda Pharmaceuticals U.S.A., Inc., Deerfield, IL, at The Liver Meeting® 2015.
Treatment with tenofovir disoproxil fumarate in late pregnancy in highly viremic mothers with hepatitis B virus (HBV) infection effectively reduced mother-to-child transmission, a study reported at The Liver Meeting® 2015.
Adult doses of sofosbuvir plus ribavirin or ledipasvir/sofosbuvir provided comparable plasma exposures and tolerable safety profile in adolescents with hepatitis C virus (HCV) infection, reported Brian Kirby, PhD, from Gilead Sciences, Foster City, CA, at The Liver Meeting® 2015.
Monotherapy with tenofovir disoproxil fumarate (TDF) was equally effective as combination therapy with emtricitabine/TDF (FTC/TDF) in patients with chronic hepatitis B virus (HBV) infection harboring lamivudine resistance mutations, a study presented at The Liver Meeting® 2015 has found.
Antiviral therapy in patients with non-cirrhotic chronic hepatitis B (CHB) and normal to minimally-elevated alanine aminotransferase (ALT) levels significantly reduced the risk of hepatocellular carcinoma, reported Joseph K. Hoang from Stanford University Medical Center, Palo Alto, CA, at The Liver Meeting® 2015.
Combination treatment with peginterferon alfa-2a (peg-IFN) and adefovir or tenofovir for 48 weeks results in a loss and greater decline in HBsAg compared to no treatment in chronic hepatitis B (CHB) patients with a low viral load (LVL), reported Annikki de Niet, MD, from Academic Medical Center, Amsterdam, Netherlands, at The Liver Meeting® 2015.
The benefits of eradicating hepatitis C virus (HCV) infection with sofosbuvir may go well beyond avoiding the damage caused by chronic liver inflammation, to include declines in glycated hemoglobin (HbA1c) and other metabolic parameters, according to a study reported at The Liver Meeting® 2015.
Statin use and liver cancer were independently associated with older age, race, higher prevalence of diabetes, liver cirrhosis, smoking, BMI, and more total healthcare utilization, a study reported at The Liver Meeting® 2015.
A rapid decline in serum/plasma lysyl oxidase-like-2 (LOXL2) levels was seen in cirrhotic patients treated with sofosbuvir (SOF)-based therapy, reported authors of a new study presented at The Liver Meting® 2015.
New data reported at The Liver Meeting® 2015 indicate that entecavir monotherapy without hepatitis B immune globulin (HBIG) effectively prevents graft loss and death from recurrent hepatitis B after liver transplantation in patients with chronic hepatitis B without prior drug resistant mutations.
Peginterferon alfa-2b (Pegberon) demonstrates non-inferior efficacy to peginterferon alfa-2a (PEG IFNα-2a) for the treatment of Chinese HBeAg-positive chronic hepatitis B (CHB) patients, reported Gui-Qiang Wang, MD, PhD, from Peking University First Hospital, Beijing, China, at The Liver Meeting® 2015.
Drinking coffee might reduce the risk of alcoholic hepatitis (AH) among heavy alcohol drinkers, according to a study reported at The Liver Meeting® 2015
Early biomarkers cystatin C and NGAL may facilitate the safe delivery of long-term nucleos(t)ide analogue (NA) therapy for patients who have undergone liver transplantation, according to a study reported at the The Liver Meeting® 2015.
Aspirin and clopidogrel therapy are associated with reduced risk of hepatocellular carcinoma (HCC) among patients with chronic hepatitis B infection, according to a study reported at the The Liver Meeting® 2015.
The combination of two next-generation direct-acting antiviral (DAA) agents, ABT-493 and ABT-530, was "well tolerated," with all non-cirrhotic patients with hepatitis C virus (HCV) genotype 1 (GT1) infection who completed the 8-week treatment period achieving sustained virologic response at 12 weeks (SVR12), a study presented at The Liver Meeting 2015® has found.
Portal vein thrombosis, a complication of cirrhosis, has an annual incidence of 4% in Spain, with risk factors being use of beta-blockers and hepatic encephalopsy, investigators reported during The Liver Meeting® 2015.
In patients with minimal hepatic encephalopathy, nutritional therapy is effective and improves HRQOL, a randomized controlled trial presented during The Liver Meeting® 2015 has reported.
Oral combination sofosbuvir (SOF) and ribavirin (RBV) therapy is "efficacious and well-tolerated" among patients with hepatitis C virus (HCV) genotype 2 or genotype 3 infection, confirmed authors of a study presented at the The Liver Meeting® 2015.
Patients with chronic hepatitis B virus (HBV) treated with tenofovir rescue monotherapy achieve antiviral efficacy rates similar to those of tenofovir-based combination rescue therapy, even in patients with multi-drug resistance, investigators reported during The Liver Meeting® 2015.
Mild or moderate renal impairment did not impact direct-acting antivirals (DAA) and ritonavir (RTV) exposures, a study presented at The Liver Meeting® 2015 found.