Topical Testosterone Tx Adherence Examined in Hypogonadal Men

Adherence to topical testosterone was associated with reaching total T lab value goals
Adherence to topical testosterone was associated with reaching total T lab value goals

This article is written live from the American Association of Clinical Endocrinologists (AACE) 2017 Annual Meeting in Austin, TX. MPR will be reporting news on the latest findings from leading experts in endocrinology. Check back for more news from AACE 2017.


A retrospective study of males with primary or secondary hypogonadism reports that low adherence to topical testosterone therapy shows an "unmet need and scope for improved health outcomes in this population of men," presented Michael Grabner, PhD, from HealthCore, Inc., at the AACE 2017 Annual Meeting.

Dr. Grabner and coauthors of the study attempted to evaluate adherence to topical testosterone therapy in a real-world cohort of commercially insured males with primary or secondary hypogonadism, and to compare baseline features and follow-up outcomes between patients who were adherent vs. non-adherent. 

Data of male patients aged ≥18 years who initiated topical testosterone therapy between January 1, 2006 and September 30, 2015 were obtained from the HealthCore Integrated Research Database. "Adherence to the initial topical testosterone therapy was defined as PDC [Proportion of Days Covered] ≥80% during 12 months of follow-up," stated Dr. Grabner. 

A total of 3,184 patients initiated on topical testosterone were identified, of which 538 (17%) patients were adherent and 2,646 (83%) were non-adherent. Patients who were adherent had a greater share of initial topical testosterone therapy prescriptions from endocrinologists vs. non-adherent patients (38% vs. 31%), and a lesser share from primary care physicians (35% vs. 44%). 

Study authors noted a lower presence of baseline comorbidity among adherent patients vs. non-adherent patients: coronary heart disease (9% vs.13%), depression (24% vs. 29%), hypertension (40% vs. 49%), insomnia (20% vs. 24%), and obesity (9% vs. 15%; all P<0.05). 

More than half of the patient subgroup with available lab data had low testosterone levels at baseline (250ng/dL). At follow-up, the adherent patient group showed a greater increase in testosterone levels vs. the non-adherent patient group (+239ng/dL vs. 165ng/dL; P<0.01). Though not statistically significant, adherence was associated with lower odds of fatigue, depression, insomnia, and osteoarthritis.

Findings from the study add to the data on suboptimal adherence to topical testosterone therapy among men with hypogonadism. "This research demonstrated that adherence is associated with greater improvement in total testosterone lab values and may be associated with lower likelihood of having certain comorbidities, thus future research should focus on ways to improve adherence among this patient population," the authors concluded.

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