AAAAI 2017

Exhalation Delivery System Compared to Conventional Nasal Spray

By March 06, 2017

EDS_FLU produced higher systemic exposure than Flonase and substantially lower systemic exposure than Flovent 440mcg, indicating that drug deposition is greatly improved with EDS vs. conventional nasal spray.

Is IL-5 Inhibition Effective in NSAIDs-Exacerbated Respiratory Disease?

By March 06, 2017

Based on the pathophysiological and clinical characteristics of N-ERD, anti-IL 5 therapy may be effective in this patient subgroup.

How Does Long-Term Attenuated Androgen Prophylaxis Affect Neoplasms, CVD Risk?

By March 06, 2017

Patients with hereditary angioedema (HAE) on long-term prophylaxis with attenuated androgen (LTP-AA) appeared to have a higher risk for cardiovascular disease but a lower number of neoplasms.

Itch Scores, Urticaria Reduced With Long-Term Omalizumab in CIU

By March 06, 2017

The XTEND-CIU study assessed patients aged ≥12 years for the safety and efficacy of longer-term omalizumab treatment (48 weeks) and helped to better understand drug discontinuation in patients with chronic idiopathic urticaria.

Recombinant HC1INH Safe, Effective for Preventing HAE Attacks

By March 06, 2017

Patients in the study were ≥13 years old, had a <50% of normal functional C1INH level, and a history of at least 4 monthly HAE attacks for at least 3 months.

Maternal Vitamin E and Childhood Asthma: What's the Link?

March 06, 2017

Association strongest for the vitamin E isoform -tocopherol, found in safflower, sunflower oils

Early vs. Late Administration of Icatibant in Patients With HAE Attack

By March 06, 2017

Analysis indicated that skin attacks were treated more frequently in early self-treaters compared to late treaters.

Improved Skin Lesions, Pruritus With Dupilumab in Atopic Dermatitis

By March 06, 2017

The study evaluated subcutaneous dupilumab 300mg given weekly up to 3 years in adults with atopic dermatitis.

High Fruit Intake May Prevent Onset of Allergic Symptoms in Children

By March 06, 2017

Food intake was categorized as low, medium, or high based on the amount consumed during the study period.

Treatment Satisfaction for New Human SC vs. IV Immunoglobulin Compared

By March 06, 2017

Two long-term studies evaluated satisfaction among PIDD patients.

Pattern of Systemic Reactions Examined During SC Immunotherapy

By March 06, 2017

Systemic reactions (SR) associated with subcutaneous immunotherapy (SCIT) were found to be mild in severity and mainly occurred during the build-up phase of IT.

Faster Relief of HAE Attacks Seen with Recombinant Human C1 Esterase Inhibitor

By March 06, 2017

Hereditary angioedema attacks were included in the pooled analysis if overall severity score reached at least 50mm on a 100mm visual analog scale.

Intranasal Sprays Compared for Allergic Rhinitis in Young Children

By March 06, 2017

Enrolled children were randomized 3:1 to the MP-AzeFlu or fluticasone propionate.

Zileuton Improves Lung Function in Aspirin-Sensitive Asthma Patients

By March 06, 2017

Aspirin-sensitive asthma patients had greater improvements in pulmonary function after treatment with zileuton CR vs. asthma patients without aspirin sensitivity.

Omalizumab May Improve Symptoms in Pollen Food Syndrome

By March 06, 2017

Omalizumab may improve symptoms in patients suffering from Pollen Food Syndrome, according to new research findings.

Epicutaneous Immunotherapy Shows Promise Against Peanut Allergy

By March 06, 2017

Epicutaneous immunotherapy (EPIT) treatment of peanut allergy with Viaskin® Peanut shows long-term safety and efficacy.

IV-to-SC C1 Inhibitor Switch for HAE Attack Prophylaxis Found Effective

By March 06, 2017

The authors analyzed data for 21 patients who had switched from C1INH(IV) for routine HAE prophylaxis to C1INH(SC) for routine prevention as part of the COMPACT trial.

Penicillin Allergy Testing Should Be Part of Pre-Op Evaluation

By March 05, 2017

Penicillin allergy is the most frequent form of drug allergy.

Possible Long-Term Benefit With Probiotic + Peanut Oral Immunotherapy in Children

By March 05, 2017

Most infants who achieved unresponsiveness at 18 months stayed symptom-free 5 years later.

SC Immunotherapy: Rate and Severity of Reactions in Elderly

By March 05, 2017

A total of 158 patients receiving SCIT to aeroallergens were included in the study.

Anti-IgE Therapy in Severe Aspirin-Exacerbated Respiratory Disease

By March 05, 2017

Dr. Taniguchi aimed to describe the pathomechanism of induction of severe airway symptoms in AERD patients and described potential mechanisms of anti-IgE (omalizumab) as a treatment for AERD.

Do Parental Allergic Diseases Affect Offspring Skin Sensitivity?

By March 05, 2017

Skin prick tests found that infants with eczema had significantly larger wheal sizes to histamine compared to infants without eczema.

Dupilumab Improves Smell Function in Chronic Rhinosinusitis with Nasal Polyps

By March 05, 2017

They evaluated dupilumab's effects on smell function with 60 patients with nasal polyps who were refractory to intranasal corticosteroids.

Allergen-Specific Immunotherapy May Cut ICS Need for Asthma in Pre-Teens

By March 05, 2017

Allergen-specific subcutaneous immunotherapy (SCIT) reduced 5- to 11-year-old children's need for inhaled corticosteroids (ICS) to manage asthma symptoms.

Peanut-Specific IgE May Help Predict ADRs With Peanut Oral Immunotherapy

By March 05, 2017

Assessment of predictive factors for systemic allergic reactions (SAR) determined that peanut oral immunotherapy (OIT) is safe in patients with peanut allergy (PA).

Breath-Actuated vs. Metered-Dose Inhaler for Beclomethasone Dipropionate Compared

By March 05, 2017

A total of 425 patients were included in both the modified intention-to-treat and safety analyses.

Supervised Self-Injection Practice Improves Patient Comfort Level with Epinephrine Use

By March 05, 2017

Supervised self-injection practice in the clinic to simulate adolescents' use of an epinephrine autoinjector to manage food allergy anaphylaxis offers immediate improvements in patients' comfort levels.

Is Add-On Tiotropium Respimat Effective in Children, Teens With Moderate Asthma?

By March 05, 2017

Adding tiotropium Respimat to maintenance therapy of inhaled corticosteroid was found to significantly improve lung function in adolescents and children.

Long-Term Safety for 5-Grass Pollen SL Tab in Allergic Rhinoconjunctivitis

By March 05, 2017

Safety data of long-term treatment with 300IR 5-grass SL tablet indicated that "the most frequent ADRs, generally mild, were reported with decreasing incidences over the years studied and could persist up to 4 months during treatment."

Improved Congestion, Polyp Grade Seen With Fluticasone Propionate EDS

By March 05, 2017

A Fluticasone Propionate Exhalation Delivery System (FLU-EDS) has shown significant improvements in patients diagnosed with Chronic Rhinosinusitis with Nasal Polyps.